Detalhe da pesquisa
1.
Mapping allosteric linkage to channel gating by extracellular domains in the human epithelial sodium channel.
J Biol Chem
; 293(10): 3675-3684, 2018 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29358325
2.
Gain-of-Function Mutation W493R in the Epithelial Sodium Channel Allosterically Reconfigures Intersubunit Coupling.
J Biol Chem
; 291(8): 3682-92, 2016 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26668308
3.
Inhibition of Protease-Epithelial Sodium Channel Signaling Improves Mucociliary Function in Cystic Fibrosis Airways.
Am J Respir Crit Care Med
; 194(6): 701-10, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27014936
4.
Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways.
Proc Natl Acad Sci U S A
; 110(40): 15973-8, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24043776
5.
The N-terminal domain allosterically regulates cleavage and activation of the epithelial sodium channel.
J Biol Chem
; 289(33): 23029-23042, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24973914
6.
Cathepsin B contributes to Na+ hyperabsorption in cystic fibrosis airway epithelial cultures.
J Physiol
; 592(23): 5251-68, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25260629
7.
Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures.
Am J Physiol Lung Cell Mol Physiol
; 305(12): L990-L1001, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24124190
8.
Nonantibiotic macrolides prevent human neutrophil elastase-induced mucus stasis and airway surface liquid volume depletion.
Am J Physiol Lung Cell Mol Physiol
; 304(11): L746-56, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23542952
9.
Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways.
FASEB J
; 26(10): 4348-59, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22798424
10.
Activation of the epithelial sodium channel (ENaC) by serine proteases.
Annu Rev Physiol
; 71: 361-79, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-18928407
11.
Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration.
Sci Transl Med
; 15(699): eabo7728, 2023 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37285404
12.
Regional differences in rat conjunctival ion transport activities.
Am J Physiol Cell Physiol
; 303(7): C767-80, 2012 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22814399
13.
Energetic and structural basis for activation of the epithelial sodium channel by matriptase.
Biochemistry
; 51(16): 3460-9, 2012 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-22471557
14.
SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage.
Proc Natl Acad Sci U S A
; 106(27): 11412-7, 2009 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-19541605
15.
The cystic fibrosis transmembrane conductance regulator impedes proteolytic stimulation of the epithelial Na+ channel.
J Biol Chem
; 285(42): 32227-32, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20709758
16.
Regulation of the epithelial Na+ channel and airway surface liquid volume by serine proteases.
Pflugers Arch
; 460(1): 1-17, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20401730
17.
Direct interaction with filamins modulates the stability and plasma membrane expression of CFTR.
J Clin Invest
; 117(2): 364-74, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17235394
18.
Cav3.2 calcium channel interactions with the epithelial sodium channel ENaC.
Mol Brain
; 12(1): 12, 2019 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30736831
19.
The N terminus of α-ENaC mediates ENaC cleavage and activation by furin.
J Gen Physiol
; 150(8): 1179-1187, 2018 08 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29980634
20.
Potential role of abnormal ion transport in the pathogenesis of chronic sinusitis.
Arch Otolaryngol Head Neck Surg
; 132(12): 1352-62, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17178948