Detalhe da pesquisa
1.
Development of a potent high-affinity human therapeutic antibody via novel application of recombination signal sequence-based affinity maturation.
J Biol Chem
; 298(2): 101533, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34973336
2.
Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
J Biol Chem
; 293(32): 12634-12646, 2018 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29794134
3.
Discovery of potent, selective, and orally bioavailable inhibitors of interleukin-1 receptor-associate kinase-4.
Bioorg Med Chem Lett
; 25(23): 5546-50, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26526214
4.
An inhibitory antibody against dipeptidyl peptidase IV improves glucose tolerance in vivo.
J Biol Chem
; 288(2): 1307-16, 2013 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23184939
5.
Structure of the nuclear factor κB-inducing kinase (NIK) kinase domain reveals a constitutively active conformation.
J Biol Chem
; 287(33): 27326-34, 2012 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-22718757
6.
Inhibiting NF-κB-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures.
Bioorg Med Chem Lett
; 23(5): 1238-44, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23374866
7.
Imidazolone as an Amide Bioisostere in the Development of ß-1,3-N-Acetylglucosaminyltransferase 2 (B3GNT2) Inhibitors.
J Med Chem
; 66(23): 16120-16140, 2023 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37988652
8.
Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies.
MAbs
; 15(1): 2256745, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37698932
9.
Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11ß-HSD1 inhibitors.
Bioorg Med Chem Lett
; 21(1): 405-10, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21093258
10.
Next generation Fc scaffold for multispecific antibodies.
iScience
; 24(12): 103447, 2021 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34877503
11.
The synthesis and SAR of novel diarylsulfone 11ß-HSD1 inhibitors.
Bioorg Med Chem Lett
; 20(23): 7071-5, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20971000
12.
AMG 701 induces cytotoxicity of multiple myeloma cells and depletes plasma cells in cynomolgus monkeys.
Blood Adv
; 4(17): 4180-4194, 2020 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32886754
13.
Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors.
Bioorg Med Chem Lett
; 19(6): 1797-801, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19217779
14.
Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma.
Bioorg Med Chem Lett
; 19(13): 3550-4, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19464171
15.
Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1).
Bioorg Med Chem Lett
; 19(5): 1522-7, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19181519
16.
Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors.
Bioorg Med Chem Lett
; 19(5): 1446-50, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19185488
17.
Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).
Bioorg Med Chem Lett
; 18(12): 3513-6, 2008 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18511278
18.
Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
Bioorg Med Chem
; 16(19): 8922-31, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18789704
19.
Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper.
Structure
; 14(12): 1835-44, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17161373
20.
Structure/function studies of phosphoryl transfer by phosphoenolpyruvate carboxykinase.
Biochim Biophys Acta
; 1697(1-2): 271-8, 2004 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-15023367