Detalhe da pesquisa
1.
Human parainfluenza virus type 1 C proteins are nonessential proteins that inhibit the host interferon and apoptotic responses and are required for efficient replication in nonhuman primates.
J Virol
; 82(18): 8965-77, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18614629
2.
Attenuation and efficacy of human parainfluenza virus type 1 (HPIV1) vaccine candidates containing stabilized mutations in the P/C and L genes.
Virol J
; 4: 67, 2007 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-17605811
3.
An improved method for the recovery of recombinant paramyxovirus vaccine candidates suitable for use in human clinical trials.
J Virol Methods
; 141(1): 30-3, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17210187
4.
Recombinant human parainfluenza virus type 2 vaccine candidates containing a 3' genomic promoter mutation and L polymerase mutations are attenuated and protective in non-human primates.
Vaccine
; 25(34): 6409-22, 2007 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-17658669
5.
Introducing point and deletion mutations into the P/C gene of human parainfluenza virus type 1 (HPIV1) by reverse genetics generates attenuated and efficacious vaccine candidates.
Vaccine
; 24(14): 2674-84, 2006 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-16364511
6.
Individual contributions of the human metapneumovirus F, G, and SH surface glycoproteins to the induction of neutralizing antibodies and protective immunity.
Virology
; 345(2): 492-501, 2006 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16300813
7.
Attenuating mutations in the P/C gene of human parainfluenza virus type 1 (HPIV1) vaccine candidates abrogate the inhibition of both induction and signaling of type I interferon (IFN) by wild-type HPIV1.
Virology
; 352(1): 61-73, 2006 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16750233
8.
Live-attenuated intranasal parainfluenza virus type 2 vaccine candidates developed by reverse genetics containing L polymerase protein mutations imported from heterologous paramyxoviruses.
Vaccine
; 23(39): 4765-74, 2005 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15964103
9.
Human parainfluenza virus type I (HPIV1) vaccine candidates designed by reverse genetics are attenuated and efficacious in African green monkeys.
Vaccine
; 23(38): 4631-46, 2005 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-15951066
10.
Evaluation of the replication and immunogenicity of recombinant human parainfluenza virus type 3 vectors expressing up to three foreign glycoproteins.
Virology
; 297(1): 136-52, 2002 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-12083844
11.
The genome length of human parainfluenza virus type 2 follows the rule of six, and recombinant viruses recovered from non-polyhexameric-length antigenomic cDNAs contain a biased distribution of correcting mutations.
J Virol
; 77(1): 270-9, 2003 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-12477832
12.
Sequence analysis of the Washington/1964 strain of human parainfluenza virus type 1 (HPIV1) and recovery and characterization of wild-type recombinant HPIV1 produced by reverse genetics.
Virus Genes
; 24(1): 77-92, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-11928991
13.
The recombinant chimeric human parainfluenza virus type 1 vaccine candidate, rHPIV3-1cp45, is attenuated, immunogenic, and protective in African green monkeys.
Vaccine
; 20(13-14): 1846-52, 2002 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-11906774
14.
Generation of recombinant human parainfluenza virus type 1 vaccine candidates by importation of temperature-sensitive and attenuating mutations from heterologous paramyxoviruses.
J Virol
; 78(4): 2017-28, 2004 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-14747566
15.
Codon substitution mutations at two positions in the L polymerase protein of human parainfluenza virus type 1 yield viruses with a spectrum of attenuation in vivo and increased phenotypic stability in vitro.
J Virol
; 78(4): 2029-36, 2004 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-14747567
16.
Determinants of the host range restriction of replication of bovine parainfluenza virus type 3 in rhesus monkeys are polygenic.
J Virol
; 77(2): 1141-8, 2003 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-12502830
17.
The two major human metapneumovirus genetic lineages are highly related antigenically, and the fusion (F) protein is a major contributor to this antigenic relatedness.
J Virol
; 78(13): 6927-37, 2004 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15194769
18.
Sendai virus, a murine parainfluenza virus type 1, replicates to a level similar to human PIV1 in the upper and lower respiratory tract of African green monkeys and chimpanzees.
Virology
; 297(1): 153-60, 2002 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-12083845