Detalhe da pesquisa
1.
Potent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen.
Antimicrob Agents Chemother
; 59(3): 1389-97, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25512421
2.
Pharmacokinetics and efficacy of the spleen tyrosine kinase inhibitor r406 after ocular delivery for retinoblastoma.
Pharm Res
; 31(11): 3060-72, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24906597
3.
Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents.
Bioorg Med Chem Lett
; 23(23): 6492-9, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24120539
4.
Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib.
Antimicrob Agents Chemother
; 56(9): 4914-21, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22777048
5.
2-Oxo-tetrahydro-1,8-naphthyridines as selective inhibitors of malarial protein farnesyltransferase and as anti-malarials.
Bioorg Med Chem Lett
; 18(2): 494-7, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18077162
6.
Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials.
J Med Chem
; 50(19): 4585-605, 2007 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-17722901
7.
Novel C-9, 9'-O-acyl esters of (-)-carinol as free-radical scavengers and xanthine oxidase enzyme inhibitors: synthesis and biological evaluation.
Med Chem
; 9(1): 100-3, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22762167
8.
Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease.
J Med Chem
; 52(12): 3703-15, 2009 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-19463001