RESUMO
Stimulating effect of I-ethoxy silatrane on healing of acetate derived stomach ulcer was studied in rats. The drug was shown to inhibit lipid peroxidation and free-radical oxidation in blood and gastric tissues as well as to accelerate reparation in ulcerous zone. I-Ethoxy silatrane interacted with artificial membranes and affected the respiration rate in liver mitochondria. Membranetropic effect of I-ethoxy silatrane appears to be involved in the drug ulcerostatic effect.
Assuntos
Antiulcerosos , Compostos Bicíclicos Heterocíclicos com Pontes , Compostos Bicíclicos com Pontes/farmacologia , Hidrocarbonetos Aromáticos com Pontes/farmacologia , Compostos de Organossilício , Silício/farmacologia , Úlcera Gástrica/tratamento farmacológico , Animais , Compostos Bicíclicos com Pontes/uso terapêutico , Colesterol/sangue , Peroxidação de Lipídeos/efeitos dos fármacos , Mitocôndrias Hepáticas/metabolismo , Consumo de Oxigênio/efeitos dos fármacos , Ratos , Silício/uso terapêutico , Úlcera Gástrica/metabolismoRESUMO
Dynamics of experimental acetate gastric ulcer healing and lipid peroxidation were studied in rat blood and gastric tissues after treatment with methyluracil. The drug was shown to stimulate reparation and to inhibit lipid peroxidation. The antiulcerogenous effects of methyluracil appear to involve the antioxidative mechanisms.
Assuntos
Mucosa Gástrica/metabolismo , Peróxidos Lipídicos/metabolismo , Úlcera Gástrica/metabolismo , Uracila/análogos & derivados , Animais , Peróxidos Lipídicos/sangue , Medições Luminescentes , Ratos , Úlcera Gástrica/sangue , Úlcera Gástrica/tratamento farmacológico , Uracila/uso terapêuticoRESUMO
Stimulating effect of 1-ethoxysilatrane on healing processes of experimental stomach ulcers was studied in rats. 1-ethoxysilatrane inhibited lipid peroxidation in blood and stomach wall tissues, interacted with artificial membranes, and affected the rate of mitochondrial respiration in liver. A hypothesis is put forward on the membranotropic effect of 1-ethoxysilatrane which underlies its ulcerostatic effect.
Assuntos
Antiulcerosos/uso terapêutico , Compostos Bicíclicos Heterocíclicos com Pontes , Compostos Bicíclicos com Pontes/uso terapêutico , Compostos de Organossilício , Silício/uso terapêutico , Acetatos , Animais , Antiulcerosos/farmacologia , Compostos Bicíclicos com Pontes/farmacologia , Avaliação Pré-Clínica de Medicamentos , Bicamadas Lipídicas , Peroxidação de Lipídeos/efeitos dos fármacos , Lipídeos de Membrana , Potenciais da Membrana/efeitos dos fármacos , Ratos , Silício/farmacologia , Úlcera Gástrica/induzido quimicamente , Úlcera Gástrica/tratamento farmacológico , Úlcera Gástrica/metabolismo , Fatores de Tempo , Cicatrização/efeitos dos fármacosRESUMO
A stimulating effect of methylethyl(silatrane-I-ilmethyl)-sulphonium iodides, 1-(ethoxy)silatranes and 1-(chloromethyl)silatrane on the processes of rat test acetate ulcer healing is studied. Silatranes efficiency is not inferior to oxyferriscorbone and exceeds that of methacil. It is shown that all preparations inhibit the processes of lipids peroxidation in the blood, in liposomes and stomach tissue.
Assuntos
Antiulcerosos , Compostos Bicíclicos Heterocíclicos com Pontes , Compostos Bicíclicos com Pontes/farmacologia , Compostos de Organossilício , Silício/farmacologia , Ácido 2,3-Dicetogulônico/farmacologia , Ácido 2,3-Dicetogulônico/uso terapêutico , Aloxano/farmacologia , Aloxano/uso terapêutico , Animais , Antiulcerosos/uso terapêutico , Compostos Bicíclicos com Pontes/uso terapêutico , Combinação de Medicamentos , Compostos Férricos/farmacologia , Compostos Férricos/uso terapêutico , Peroxidação de Lipídeos/efeitos dos fármacos , Ratos , Silício/uso terapêutico , Úlcera Gástrica/tratamento farmacológico , Uracila/análogos & derivados , Uracila/farmacologia , Uracila/uso terapêuticoRESUMO
It has been demonstrated in rats with experimental gastric ulcer that 1-(chloromethyl) silatrane intensifies the development of granulation-fibrous tissue and favours optimization of the ratio of collagens and glycosaminoglycans, the main connective tissue biopolymers. Furthermore, 1-(chloromethyl) silatrane produces a more pronounced effect on hexosamine-containing glycoproteins in the ulcer tissue as compared with methyluracil and oxyferriscorbon. At the same time, judging by the time course of sialoproteins, the antiulcerous drugs, methyluracil and oxyferriscorbon, are much more effective antiinflammatory agents than 1-(chloromethyl)silatrane.