Detalhe da pesquisa
1.
Precise druggability of the PTH type 1 receptor.
Nat Chem Biol
; 18(3): 272-280, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34949836
2.
Biased GPCR signaling by the native parathyroid hormone-related protein 1 to 141 relative to its N-terminal fragment 1 to 36.
J Biol Chem
; 298(9): 102332, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35933010
3.
Domain-Selective BET Ligands Yield Next-Generation Synthetic Genome Readers/Regulators with Nonidentical Cellular Functions.
J Am Chem Soc
; 2023 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37923569
4.
Shining light on location-biased cAMP signaling.
J Biol Chem
; 297(3): 101118, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34437901
5.
Allosteric interactions in the parathyroid hormone GPCR-arrestin complex formation.
Nat Chem Biol
; 16(10): 1096-1104, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32632293
6.
Ca2+ allostery in PTH-receptor signaling.
Proc Natl Acad Sci U S A
; 116(8): 3294-3299, 2019 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30718391
7.
Structural insights into emergent signaling modes of G protein-coupled receptors.
J Biol Chem
; 295(33): 11626-11642, 2020 08 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32571882
8.
Development of C-type lectin-oriented surfaces for high avidity glycoconjugates: towards mimicking multivalent interactions on the cell surface.
Org Biomol Chem
; 18(25): 4763-4772, 2020 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32608454
9.
Polyvalent C-glycomimetics based on l-fucose or d-mannose as potent DC-SIGN antagonists.
Org Biomol Chem
; 15(18): 3995-4004, 2017 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28443908
10.
Structure of a glycomimetic ligand in the carbohydrate recognition domain of C-type lectin DC-SIGN. Structural requirements for selectivity and ligand design.
J Am Chem Soc
; 135(7): 2518-29, 2013 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23360500
11.
Selective targeting of dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) with mannose-based glycomimetics: synthesis and interaction studies of bis(benzylamide) derivatives of a pseudomannobioside.
Chemistry
; 19(15): 4786-97, 2013 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23417900
12.
Synthesis of a selective inhibitor of a fucose binding bacterial lectin from Burkholderia ambifaria.
Org Biomol Chem
; 11(24): 4086-94, 2013 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23673818
13.
Molecular Mechanisms of PTH/PTHrP Class B GPCR Signaling and Pharmacological Implications.
Endocr Rev
; 44(3): 474-491, 2023 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36503956
14.
Pseudosaccharide functionalized dendrimers as potent inhibitors of DC-SIGN dependent Ebola pseudotyped viral infection.
Bioconjug Chem
; 22(7): 1354-65, 2011 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-21650462
15.
Second generation of fucose-based DC-SIGN ligands: affinity improvement and specificity versus Langerin.
Org Biomol Chem
; 9(16): 5778-86, 2011 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21735039
16.
Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation.
Sci Signal
; 14(703): eabc5944, 2021 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34609896
17.
PTH/PTHrP Receptor Signaling, Allostery, and Structures.
Trends Endocrinol Metab
; 30(11): 860-874, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31699241
18.
Structure and dynamics of the active human parathyroid hormone receptor-1.
Science
; 364(6436): 148-153, 2019 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30975883
19.
Nonhydrolyzable C-disaccharides, a new class of DC-SIGN ligands.
Carbohydr Res
; 435: 7-18, 2016 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-27676269
20.
Transmission electron microscopy for the evaluation and optimization of crystal growth.
Acta Crystallogr D Struct Biol
; 72(Pt 5): 603-15, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27139624