Detalhe da pesquisa
1.
An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human ß-Factor XIIa in a Cyclotide Scaffold.
J Am Chem Soc
; 143(44): 18481-18489, 2021 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34723512
2.
Application and Structural Analysis of Triazole-Bridged Disulfide Mimetics in Cyclic Peptides.
Angew Chem Int Ed Engl
; 59(28): 11273-11277, 2020 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32270580
3.
KLK4 Inhibition by Cyclic and Acyclic Peptides: Structural and Dynamical Insights into Standard-Mechanism Protease Inhibitors.
Biochemistry
; 58(21): 2524-2533, 2019 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31058493
4.
Characterising the Subsite Specificity of Urokinase-Type Plasminogen Activator and Tissue-Type Plasminogen Activator using a Sequence-Defined Peptide Aldehyde Library.
Chembiochem
; 20(1): 46-50, 2019 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30225958
5.
Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro.
J Biol Chem
; 291(30): 15778-87, 2016 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27226591
6.
Structural and functional characterization of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies.
Biopolymers
; 108(1)2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27487329
7.
The evolution of Momordica cyclic peptides.
Mol Biol Evol
; 32(2): 392-405, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25376175
8.
Exploring the active site binding specificity of kallikrein-related peptidase 5 (KLK5) guides the design of new peptide substrates and inhibitors.
Biol Chem
; 397(12): 1237-1249, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26894578
9.
Diverse cyclic seed peptides in the Mexican zinnia (Zinnia haageana).
Biopolymers
; 106(6): 806-817, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27352920
10.
Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition.
Biochem J
; 469(2): 243-53, 2015 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25981970
11.
Mechanism-based selection of a potent kallikrein-related peptidase 7 inhibitor from a versatile library based on the sunflower trypsin inhibitor SFTI-1.
Biopolymers
; 100(5): 510-8, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24078181
12.
Mechanism-based selection of a potent kallikrein-related peptidase 7 inhibitor from a versatile library based on the sunflower trypsin inhibitor SFTI-1.
Biopolymers
; 2013 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23494567
13.
Natural and engineered plasmin inhibitors: applications and design strategies.
Chembiochem
; 13(3): 336-48, 2012 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22238174
14.
Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14.
Biol Chem
; 393(5): 331-41, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22505516
15.
Plasmin substrate binding site cooperativity guides the design of potent peptide aldehyde inhibitors.
Biochemistry
; 50(39): 8454-62, 2011 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21877690
16.
Natural and engineered kallikrein inhibitors: an emerging pharmacopoeia.
Biol Chem
; 391(4): 357-74, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20180638
17.
Binding Loop Substitutions in the Cyclic Peptide SFTI-1 Generate Potent and Selective Chymase Inhibitors.
J Med Chem
; 63(2): 816-826, 2020 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31855419
18.
Iterative Optimization of the Cyclic Peptide SFTI-1 Yields Potent Inhibitors of Neutrophil Proteinase 3.
ACS Med Chem Lett
; 10(8): 1234-1239, 2019 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31413811
19.
Amino Acid Scanning at P5' within the Bowman-Birk Inhibitory Loop Reveals Specificity Trends for Diverse Serine Proteases.
J Med Chem
; 62(7): 3696-3706, 2019 04 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30888159
20.
Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
J Med Chem
; 62(2): 552-560, 2019 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30520638