Detalhe da pesquisa
1.
2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2.
Bioorg Med Chem Lett
; 19(23): 6529-33, 2009 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19857967
2.
Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases.
J Med Chem
; 58(18): 7195-216, 2015 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26230873
3.
Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism.
Structure
; 18(9): 1083-93, 2010 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20826335
4.
Phenotypic characterization of resistant Val36 variants of hepatitis C virus NS3-4A serine protease.
Antimicrob Agents Chemother
; 52(1): 110-20, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17938182
5.
Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships.
J Med Chem
; 51(17): 5243-63, 2008 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18690678
6.
Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha.
J Biol Chem
; 282(31): 22619-28, 2007 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-17556358
7.
The structure of dimeric ROCK I reveals the mechanism for ligand selectivity.
J Biol Chem
; 281(1): 260-8, 2006 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16249185
8.
Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.
J Biol Chem
; 280(14): 13728-34, 2005 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-15657054
9.
Structure of the CoA transferase from pig heart to 1.7 A resolution.
Acta Crystallogr D Biol Crystallogr
; 60(Pt 10): 1717-25, 2004 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15388917
10.
The structural basis for autoinhibition of FLT3 by the juxtamembrane domain.
Mol Cell
; 13(2): 169-78, 2004 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-14759363
11.
Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase.
Antimicrob Agents Chemother
; 48(5): 1856-64, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15105144
12.
Crystal structure of aurora-2, an oncogenic serine/threonine kinase.
J Biol Chem
; 277(45): 42419-22, 2002 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-12237287
13.
Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export.
J Biol Chem
; 277(40): 37401-5, 2002 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-12171911