Detalhe da pesquisa
1.
Intrahepatic Transcriptional Signature Associated with Response to Interferon-α Treatment in the Woodchuck Model of Chronic Hepatitis B.
PLoS Pathog
; 11(9): e1005103, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26352406
2.
Insights into kinetic mechanism of Janus kinase 3 and its inhibition by tofacitinib.
Arch Biochem Biophys
; 612: 22-34, 2016 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27555492
3.
Radioligand binding to intact cells as a tool for extended drug screening in a representative physiological context.
Drug Discov Today Technol
; 17: 28-34, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26724334
4.
Contrasting roles of mitogen-activated protein kinases in cellular entry and replication of hepatitis C virus: MKNK1 facilitates cell entry.
J Virol
; 87(8): 4214-24, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23365451
5.
Correction: Intrahepatic Transcriptional Signature Associated with Response to Interferon-α Treatment in the Woodchuck Model of Chronic Hepatitis B.
PLoS Pathog
; 12(3): e1005541, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-27022978
6.
Transcriptomic analysis of the woodchuck model of chronic hepatitis B.
Hepatology
; 56(3): 820-30, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22431061
7.
Characterization of the elongation complex of dengue virus RNA polymerase: assembly, kinetics of nucleotide incorporation, and fidelity.
J Biol Chem
; 286(3): 2067-77, 2011 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21078673
8.
Why medicines work.
Pharmacol Ther
; 238: 108175, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35351464
9.
3-Amino-pyrazolo[3,4-d]pyrimidines as p38α kinase inhibitors: design and development to a highly selective lead.
Bioorg Med Chem Lett
; 21(11): 3452-6, 2011 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21515047
10.
Steady-state kinetic characterization of kinase activity and requirements for Mg2+ of interleukin-1 receptor-associated kinase-4.
Biochemistry
; 49(7): 1495-506, 2010 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20104875
11.
Fluxes for Unraveling Complex Binding Mechanisms.
Trends Pharmacol Sci
; 41(12): 923-932, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33153779
12.
Recent advances in phenotypic drug discovery.
F1000Res
; 92020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32850117
13.
Development of a Bioluminescent High-Throughput Screening Assay for Nicotinamide Mononucleotide Adenylyltransferase (NMNAT).
SLAS Discov
; 25(1): 33-42, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31583955
14.
Biochemical mechanisms of drug action: what does it take for success?
Nat Rev Drug Discov
; 3(9): 801-8, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15340390
15.
Biochemical mechanisms of New Molecular Entities (NMEs) approved by United States FDA during 2001-2004: mechanisms leading to optimal efficacy and safety.
Curr Top Med Chem
; 6(5): 461-78, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16719803
16.
Enzyme Activity Assays for Protein Kinases: Strategies to Identify Active Substrates.
Curr Drug Discov Technol
; 13(1): 2-15, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26768716
17.
On the different experimental manifestations of two-state 'induced-fit' binding of drugs to their cellular targets.
Br J Pharmacol
; 173(8): 1268-85, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26808227
18.
Glycogen Synthase Kinase 3ß Promotes the Endocytosis of Transferrin in the African Trypanosome.
ACS Infect Dis
; 2(7): 518-28, 2016 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27626104
19.
A Four-Point Screening Method for Assessing Molecular Mechanism of Action (MMOA) Identifies Tideglusib as a Time-Dependent Inhibitor of Trypanosoma brucei GSK3ß.
PLoS Negl Trop Dis
; 10(3): e0004506, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26942720
20.
Bi-substrate kinetic analysis of an E3-ligase-dependent ubiquitylation reaction.
Methods Enzymol
; 399: 323-33, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-16338366