Detalhe da pesquisa
1.
Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles.
J Virol
; 97(10): e0072223, 2023 10 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37754761
2.
Class A capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation.
Hepatology
; 78(4): 1252-1265, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37102495
3.
Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models.
Int J Mol Sci
; 24(22)2023 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38003463
4.
ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model.
Biochem Biophys Res Commun
; 555: 134-139, 2021 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33813272
5.
Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase.
PLoS Pathog
; 14(2): e1006889, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29425244
6.
Antiviral Activity, Safety, and Pharmacokinetics of AL-794, a Novel Oral Influenza Endonuclease Inhibitor: Results of an Influenza Human Challenge Study.
J Infect Dis
; 219(2): 177-185, 2019 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30053042
7.
Respiratory syncytial virus-A dynamics and the effects of lumicitabine, a nucleoside viral replication inhibitor, in experimentally infected humans.
J Antimicrob Chemother
; 74(2): 442-452, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30376079
8.
Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study.
N Engl J Med
; 373(21): 2048-58, 2015 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26580997
9.
Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate.
PLoS Pathog
; 11(6): e1004995, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26098424
10.
An in vivo duck hepatitis B virus model recapitulates key aspects of nucleic acid polymer treatment outcomes in chronic hepatitis B patients.
Antiviral Res
; 224: 105835, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38401714
11.
Lumicitabine, an orally administered nucleoside analog, in infants hospitalized with respiratory syncytial virus (RSV) infection: Safety, efficacy, and pharmacokinetic results.
PLoS One
; 18(7): e0288271, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37467213
12.
The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir.
mBio
; 14(1): e0281522, 2023 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36625640
13.
Mechanism of action of hepatitis B virus S antigen transport-inhibiting oligonucleotide polymer, STOPS, molecules.
Mol Ther Nucleic Acids
; 27: 335-348, 2022 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35024245
14.
Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development.
Antiviral Res
; 187: 105020, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33515606
15.
Regulation of gene transcription by thyroid hormone receptor ß agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH).
PLoS One
; 15(12): e0240338, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33306682
16.
Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry.
Antiviral Res
; 182: 104924, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32896566
17.
Innovation and trends in the development and approval of antiviral medicines: 1987-2017 and beyond.
Antiviral Res
; 155: 76-88, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29758235
18.
Phase I study on safety and pharmacokinetics of a novel influenza endonuclease inhibitor, AL-794 (JNJ-64155806), following single- and multiple-ascending doses in healthy adults.
Antivir Ther
; 23(7): 555-566, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29927386
19.
Activation Pathway of a Nucleoside Analog Inhibiting Respiratory Syncytial Virus Polymerase.
ACS Chem Biol
; 12(1): 83-91, 2017 01 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28103684
20.
Structure-activity relationship analysis of mitochondrial toxicity caused by antiviral ribonucleoside analogs.
Antiviral Res
; 143: 151-161, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28412183