Detalhe da pesquisa
1.
CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition.
Nature
; 604(7907): 749-756, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35444283
2.
Identification of secreted bacterial proteins by noncanonical amino acid tagging.
Proc Natl Acad Sci U S A
; 111(1): 433-8, 2014 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24347637
3.
Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.
J Med Chem
; 65(15): 10251-10284, 2022 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35880755
4.
Cleavable biotin probes for labeling of biomolecules via azide-alkyne cycloaddition.
J Am Chem Soc
; 132(51): 18351-60, 2010 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-21141861
5.
Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: a synergistic hydrophobic effect against resistant bacteria.
Bioorg Med Chem Lett
; 20(23): 7097-101, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20970332
6.
Structure-based design, synthesis, and A-site rRNA cocrystal complexes of functionally novel aminoglycoside antibiotics: C2" ether analogues of paromomycin.
J Med Chem
; 50(10): 2352-69, 2007 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-17458946
7.
A BODIPY-cyclooctyne for protein imaging in live cells.
Chembiochem
; 12(14): 2137-9, 2011 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21830285
8.
Live-cell imaging of cellular proteins by a strain-promoted azide-alkyne cycloaddition.
Chembiochem
; 11(15): 2092-5, 2010 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-20836119
9.
Natural products in medicine: transformational outcome of synthetic chemistry.
J Med Chem
; 57(22): 9292-308, 2014 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25144261
10.
Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site.
Angew Chem Int Ed Engl
; 43(48): 6735-8, 2004 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-15593140
11.
Synthesis and comparative antibacterial activity of verdamicin C2 and C2a. A new oxidation of primary allylic azides in dihydro[2H]pyrans.
Org Lett
; 11(2): 429-32, 2009 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19072132
12.
Crystal structure of the bacterial ribosomal decoding site complexed with a synthetic doubly functionalized paromomycin derivative: a new specific binding mode to an a-minor motif enhances in vitro antibacterial activity.
ChemMedChem
; 2(11): 1631-8, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17722211
13.
6-hydroxy to 6'''-amino tethered ring-to-ring macrocyclic aminoglycosides as probes for APH(3')-IIIa kinase.
Bioorg Med Chem Lett
; 17(11): 3221-5, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17400454
14.
Inhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues.
ChemMedChem
; 6(11): 1961-6, 2011 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21905229