Detalhe da pesquisa
1.
Thromboxane A2 receptor-mediated release of matrix metalloproteinase-1 (MMP-1) induces expression of monocyte chemoattractant protein-1 (MCP-1) by activation of protease-activated receptor 2 (PAR2) in A549 human lung adenocarcinoma cells.
Mol Carcinog
; 53(8): 659-66, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23475608
2.
Preparation and in vivo characterization of a cocaine hydrolase engineered from human butyrylcholinesterase for metabolizing cocaine.
Biochem J
; 453(3): 447-54, 2013 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23849058
3.
Prostaglandin catabolic enzymes as tumor suppressors.
Cancer Metastasis Rev
; 30(3-4): 409-17, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22020925
4.
15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors.
Proc Natl Acad Sci U S A
; 106(23): 9409-13, 2009 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-19470469
5.
Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine.
Mol Pharmacol
; 79(2): 290-7, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20971807
6.
Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs).
Prostaglandins Other Lipid Mediat
; 96(1-4): 37-40, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21763448
7.
Novel human mPGES-1 inhibitors identified through structure-based virtual screening.
Bioorg Med Chem
; 19(20): 6077-86, 2011 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21920764
8.
Interleukin-4 up-regulates 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in human lung cancer cells.
Exp Cell Res
; 316(14): 2251-9, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20632471
9.
Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors.
Bioorg Med Chem
; 18(4): 1428-33, 2010 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20122835
10.
Free-energy perturbation simulation on transition states and redesign of butyrylcholinesterase.
Biophys J
; 96(5): 1931-8, 2009 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-19254552
11.
Activation of thromboxane A(2) receptors induces orphan nuclear receptor Nurr1 expression and stimulates cell proliferation in human lung cancer cells.
Carcinogenesis
; 30(9): 1606-13, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19570744
12.
Bile acids inhibit NAD+-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes.
Am J Physiol Gastrointest Liver Physiol
; 297(3): G559-66, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19608733
13.
15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells.
Arch Biochem Biophys
; 487(2): 139-45, 2009 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19501039
14.
Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.
Mol Endocrinol
; 22(1): 105-12, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17872381
15.
Inhibition of epidermal growth factor receptor signaling elevates 15-hydroxyprostaglandin dehydrogenase in non-small-cell lung cancer.
Cancer Res
; 67(12): 5587-93, 2007 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17575121
16.
Early pregnancy loss in 15-hydroxyprostaglandin dehydrogenase knockout (15-HPGD-/-) mice due to requirement for embryo 15-HPGD activity.
Sci Rep
; 9(1): 17612, 2019 11 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31772225
17.
Most efficient cocaine hydrolase designed by virtual screening of transition states.
J Am Chem Soc
; 130(36): 12148-55, 2008 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18710224
18.
15-Hydroxyprostaglandin dehydrogenase suppresses K-RasV12-dependent tumor formation in Nu/Nu mice.
Mol Carcinog
; 47(6): 466-77, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18058808
19.
15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer.
Cancer Res
; 66(15): 7818-23, 2006 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16885386
20.
Activation of extracellular signal-regulated kinase by 12-hydroxyheptadecatrienoic acid in prostate cancer PC3 cells.
Arch Biochem Biophys
; 467(1): 20-30, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17880908