RESUMO
As a part of our program to discover novel analogues of 7-azaindole (1H-Pyrrolo[2,3-b] pyridine) having useful biological activities, some derivatives have been synthesized and evaluated for their analgesic and hypotensive activity. Compounds evaluated by thermal stimuli (tail immersion method) at the dose of 50 mg/kg of body weight revealed significant analgesic activity. Pethidine was used as reference drug. Same compounds tested at the dose of 75 mg/kg of body weight showed toxicity. Compounds tested for their effect on blood pressure in normotensive rat produced slight fall in blood pressure.
Assuntos
Analgésicos/síntese química , Anti-Hipertensivos/síntese química , Compostos Aza/síntese química , Indóis/síntese química , Analgésicos/farmacologia , Animais , Anti-Hipertensivos/farmacologia , Compostos Aza/farmacologia , Pressão Sanguínea/efeitos dos fármacos , Indóis/farmacologia , Injeções Intraperitoneais , Masculino , Camundongos , Medição da Dor , Ratos , Ratos WistarRESUMO
The neuropharmacologic profile of harmala alkaloids has been studied and found to have central effects like convulsions, catalepsy, or altered startle response. In number of studies the effects of diazepam, on harmaline and other beta carboline containing compounds-induced tremors were investigated. The present study was undertaken to examine the effect of diazepam on pretreated animals with harmaline and its synthesized phenacyl and coumarine analogues. Diazepam successfully inhibited the tremor and convulsions and attenuated the other behavioural response produced by harmaline and its derivatives.
RESUMO
In the present study two phenacyl derivatives of Harmaline; 2-(7-Methoxy-1-methyl-1,3,4,9-tetrahydro-beta-carbolin-2-yl)-1-(3-nitro-phenyl)-ethanone and 1-(3,4-Dihydroxy-phenyl)-2-(7-methoxy-1-methyl-1,3,4,9-tetrahydro-beta-carbolin-2-yl)-ethanone were synthesized and evaluated for their effect on behaviour of mice, only meta-nitro phenacyl derivative showed activity, which can be compared with parent compound.