Detalhe da pesquisa
1.
Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks.
Biochem J
; 481(6): 437-460, 2024 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38372302
2.
Identification of a novel spirocyclic Nek2 inhibitor using high throughput virtual screening.
Bioorg Med Chem Lett
; 88: 129288, 2023 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37094724
3.
Nek2 Kinase Signaling in Malaria, Bone, Immune and Kidney Disorders to Metastatic Cancers and Drug Resistance: Progress on Nek2 Inhibitor Development.
Molecules
; 27(2)2022 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35056661
4.
2-O, 3-O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1-compromised macrophage function.
Mol Med
; 27(1): 79, 2021 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34271850
5.
Synthesis of 2,3-dihydrobenzo[b][1,4]dioxine-5-carboxamide and 3-oxo-3,4-dihydrobenzo[b][1,4]oxazine-8-carboxamide derivatives as PARP1 inhibitors.
Bioorg Chem
; 102: 104075, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32777641
6.
The molluscum contagiosum virus death effector domain containing protein MC160 RxDL motifs are not required for its known viral immune evasion functions.
Virus Genes
; 53(4): 522-531, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28425034
7.
Correction to: 2O, 3O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1compromised macrophage function.
Mol Med
; 27(1): 98, 2021 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34479472
8.
Discovery of conjugated thiazolidinone-thiadiazole scaffold as anti-dengue virus polymerase inhibitors.
Biochem Biophys Res Commun
; 469(3): 743-7, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26697747
9.
Characterization of Solid Dispersion of Itraconazole Prepared by Solubilization in Concentrated Aqueous Solutions of Weak Organic Acids and Drying.
Pharm Res
; 33(6): 1456-71, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26951566
10.
Dual inhibition of Staphylococcus aureus DNA gyrase and topoisomerase IV activity by phenylalanine-derived (Z)-5-arylmethylidene rhodanines.
Bioorg Med Chem
; 23(18): 6125-37, 2015 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26320664
11.
Anti-cancer and anti-hepatitis C virus NS5B polymerase activity of etodolac 1,2,4-triazoles.
J Enzyme Inhib Med Chem
; 30(5): 778-85, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25676325
12.
Novel 4-thiazolidinones as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase.
Arch Pharm (Weinheim)
; 348(1): 10-22, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25449674
13.
ARRY-334543 reverses multidrug resistance by antagonizing the activity of ATP-binding cassette subfamily G member 2.
J Cell Biochem
; 115(8): 1381-91, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24939447
14.
WHI-P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells.
Cancer Sci
; 105(8): 1071-8, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24903205
15.
Design, synthesis, and biological evaluation of (S)-valine thiazole-derived cyclic and noncyclic peptidomimetic oligomers as modulators of human P-glycoprotein (ABCB1).
Chembiochem
; 15(1): 157-69, 2014 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24288265
16.
Pharmacophore modeling of nilotinib as an inhibitor of ATP-binding cassette drug transporters and BCR-ABL kinase using a three-dimensional quantitative structure-activity relationship approach.
Mol Pharm
; 11(7): 2313-22, 2014 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24865254
17.
Lamellarin O, a pyrrole alkaloid from an Australian marine sponge, Ianthella sp., reverses BCRP mediated drug resistance in cancer cells.
Mar Drugs
; 12(7): 3818-37, 2014 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24979269
18.
A PARP2-specific active site α-helix melts to permit DNA damage-induced enzymatic activation.
bioRxiv
; 2024 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38826291
19.
Saracatinib (AZD0530) is a potent modulator of ABCB1-mediated multidrug resistance in vitro and in vivo.
Int J Cancer
; 132(1): 224-35, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22623106
20.
The synthesis and SAR study of phenylalanine-derived (Z)-5-arylmethylidene rhodanines as anti-methicillin-resistant Staphylococcus aureus (MRSA) compounds.
Bioorg Med Chem Lett
; 23(20): 5523-7, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24012180