Corrigendum to "Determination of Serum Lost Goodwill Target Proteome in Patients with Severe Traumatic Brain Injury".

[This corrects the article DOI: 10.1155/2015/183821.].

Effect of exercise on early rehabilitation of patients with neurological disorders / Efeito do exercício na reabilitação precoce de pacientes com desordens neurológicas / Efecto del ejercicio en la rehabilitación temprana de pacientes con trastornos neurológicos

ABSTRACT Introduction: Acute cerebral infarction refers to the deficiency of the blood supply to the brain and the damage of tissue function. Objective: To study the effect of exercise training in early rehabilitation of patients with hemiplegia treated in the neurology department. Methods: Ninety-six patients with acute cerebral infarction hemiplegia were studied. According to the order of admission, 96 patients were divided into a control group and an early recovery group, with 48 patients in each group. Results: Before early rehabilitation, there was no statistical significance in NIHSS and FUGL-Meyer scores between the two groups (P > 0.05). After early rehabilitation,the NIHSS score of early rehabilitation group was lower than both its pre-early-rehab score and the control group score, while the FUGL-Meyer score was higher than both its pre-early-rehab and the control group score (P<0.05). Before early rehabilitation, there was no significant difference in the GQOLI-74 score between the two groups (P > 0.05). After early rehabilitation, the GQOLI-74 score was higher in the early rehabilitation group than both its pre-early-rehab score and the control group score (P<0.05). Conclusions: The clinical effect of early rehabilitation training in acute cerebral infarction patients with hemiplegia is significant and can further improve the clinical treatment of patients and their quality of life. Level of evidence II; Therapeutic studies - investigation of treatment results.

RESUMO Introdução: O infarto cerebral agudo refere-se à deficiência do fornecimento de sangue para o cérebro e ao dano da função tecidual. Objetivo: Estudar o efeito do treinamento físico na reabilitação precoce de pacientes com hemiplegia tratados no departamento de neurologia. Métodos: Foram estudados 96 pacientes com hemiplegia por infarto cerebral agudo. De acordo com a ordem de admissão, 96 pacientes foram divididos em grupo controle e grupo recuperação precoce, com 48 pacientes em cada grupo. Resultados: Antes da reabilitação precoce, não havia significância estatística nos escores NIHSS e FUGL-Meyer entre os dois grupos (P > 0,05). Depois da reabilitação precoce, o escore NIHSS do grupo reabilitação precoce foi menor do que o escore antes da reabilitação precoce e o escore do grupo controle, enquanto o escore FUGL-Meyer foi maior do que antes da reabilitação precoce e do grupo controle (P < 0,05). Antes da reabilitação precoce, não houve diferença significativa no escore GQOLI-74 entre os dois grupos (P > 0,05). Depois da reabilitação precoce, o escore GQOLI-74 foi maior no grupo reabilitação precoce do que antes da reabilitação precoce e no grupo controle (P < 0,05). Conclusões: O efeito clínico do treinamento de reabilitação precoce em pacientes com infarto cerebral agudo com hemiplegia é significativo e pode melhorar ainda mais o tratamento clínico dos pacientes e sua qualidade de vida. Nível de Evidência II; Estudos terapêuticos - Investigação dos resultados do tratamento.

RESUMEN Introducción: El infarto cerebral agudo se refiere a la deficiencia del suministro de sangre al cerebro y al daño de la función del tejido. Objetivo: Estudiar el efecto del entrenamiento físico en la rehabilitación temprana de pacientes con hemiplejia tratados en el departamento de neurología. Métodos: Se estudiaron noventa y seis pacientes con hemiplejia por infarto cerebral agudo. Según el orden de ingreso, se dividieron 96 pacientes en grupo de control y grupo de recuperación temprana, con 48 pacientes en cada grupo. Resultados: Antes de la rehabilitación temprana, no hubo significancia estadística en las puntuaciones de NIHSS y FUGL-Meyer entre los dos grupos (P > 0,05). Después de la rehabilitación temprana, la puntuación NIHSS del grupo de rehabilitación temprana fue menor que la puntuación antes de la rehabilitación temprana y la puntuación del grupo de control, mientras que la puntuación FUGL-Meyer fue mayor que antes de la rehabilitación temprana y el grupo de control (P < 0,05). Antes de la rehabilitación temprana, no hubo diferencias significativas en la puntuación GQOLI-74 entre los dos grupos (P > 0,05). Después de la rehabilitación temprana, la puntuación GQOLI-74 fue mayor en el grupo de rehabilitación temprana que antes de la rehabilitación temprana y en el grupo de control (P < 0,05). Conclusiones: El efecto clínico del entrenamiento de rehabilitación temprana en pacientes con infarto cerebral agudo con hemiplejia es significativo y puede mejorar aún más el tratamiento clínico y la calidad de vida de los pacientes. Nivel de Evidencia II; Estudios terapéuticos - Investigación de los resultados del tratamiento.

LRIG3 modulates proliferation, apoptosis and invasion of glioblastoma cells as a potent tumor suppressor.

Leucine-rich repeats and immunoglobulin-like domains (LRIG) 3 gene is mapped to chromosome 12q13.2, a region that is frequently deleted in a subset of glioblastoma multiforme (GBM). It has been reported that perinuclear LRIG3 staining correlated with low WHO grade of glioma and better survival of the patients. However, the relationship between LRIG3 and glioma is not very clear. The purpose of this study is to demonstrate the impacts of LRIG3 on biological characteristics of glioma and its possible mechanisms. We found that transduction of LRIG3 into glioblastoma cells inhibited cell growth in vitro and in vivo, promoted cell apoptosis, and restrained cell invasion and migration. Further studies demonstrated that LRIG3 negatively regulated the epidermal growth factor receptor (EGFR) signaling pathway. Inhibition of EGFR could reduce the effects of LRIG3 knockdown on cell proliferation and EGFR signaling pathway. In conclusion, LRIG3 functions as a tumor suppressor by attenuating EGFR signaling pathway and the restoration of LRIG3 may offer therapeutic potential against malignant gliomas.

Determination of Serum Lost Goodwill Target Proteome in Patients with Severe Traumatic Brain Injury.

This study investigates the biokinetics of LGT proteome, a potential biomarker of severe TBI, in serum of severe TBI patients. The LGT proteome presents in the serum of severe TBI patients. The abundance diversity of LGT proteome is closely associated with pathologic condition of TBI patients. Serum LGT proteome may be used as a promising marker for evaluating severity of severe TBI.

Soluble LRIG2 ectodomain is released from glioblastoma cells and promotes the proliferation and inhibits the apoptosis of glioblastoma cells in vitro and in vivo in a similar manner to the full-length LRIG2.

The human leucine-rich repeats and immunoglobulin-like domains (LRIG) gene family contains LRIG1, 2 and 3, encoding integral membrane proteins with an ectodomain, a transmembrane domain and a cytoplasmic tail. LRIG1 negatively regulates multiple receptor tyrosine kinases signaling including the epidermal growth factor receptor (EGFR) and is a proposed tumor suppressor. The soluble LRIG1 ectodomain is demonstrated to be shed naturally and inhibit the progression of glioma. However, little is known regarding the functions of LRIG2. In oligodendroglioma, LRIG2 expression is associated with poor survival, suggesting that LRIG2 might have different functions compared with LRIG1. Since soluble LRIG1 ectodomain has a similar function to the full-length LRIG1, we hypothesize that the different roles exerted by LRIG2 and LRIG1 result from the difference of their ectodomains. Here, we addressed the functions of LRIG2 and LRIG2 ectodomain in the proliferation and apoptosis of glioma and the possible underlying mechanisms. Firstly, we found that LRIG2 expression levels positively correlated with the grade of glioma. Further, we demonstrated for the first time that soluble LRIG2 ectodomain was capable of being released from glioblastoma cells and exerted a pro-proliferative effect. Overexpression of LRIG2 ectodomain promoted the proliferation and inhibited the apoptosis of glioblastoma cells in vitro and in vivo in a similar manner to the full-length LRIG2. Both full-length LRIG2 and LRIG2 ectodomain were found to physically interact with EGFR, enhance the activation of EGFR and its downstream PI3 K/Akt pathway. To our knowledge, this is the first report demonstrating that soluble LRIG2 ectodomain is capable of being released from glioblastoma cells and exerts a similar role to the full-length LRIG2 in the regulation of EGFR signaling in the progression of glioblastoma. LRIG2 ectodomain, with potent pro-tumor effects, holds promise for providing a new therapeutic target for the treatment of glioblastoma.