Detalhe da pesquisa
1.
Discovery of novel furanylbenzamide inhibitors that target oncogenic tyrosine phosphatase SHP2 in leukemia cells.
J Biol Chem
; 298(1): 101477, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34896393
2.
A cellular target engagement assay for the characterization of SHP2 (PTPN11) phosphatase inhibitors.
J Biol Chem
; 295(9): 2601-2613, 2020 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31953320
3.
Development of a Robust High-Throughput Screening Platform for Inhibitors of the Striatal-Enriched Tyrosine Phosphatase (STEP).
Int J Mol Sci
; 22(9)2021 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33922601
4.
Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease.
PLoS Biol
; 12(8): e1001923, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25093460
5.
Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis.
Circulation
; 131(7): 656-68, 2015 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25520375
6.
Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.
Bioorg Med Chem
; 23(12): 2786-97, 2015 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25921264
7.
LYP inhibits T-cell activation when dissociated from CSK.
Nat Chem Biol
; 8(5): 437-46, 2012 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22426112
8.
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant.
Nat Genet
; 37(12): 1317-9, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16273109
9.
Enzyme mechanistic studies of NMA1982, a protein tyrosine phosphatase and potential virulence factor in Neisseria meningitidis.
Sci Rep
; 13(1): 22015, 2023 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38086986
10.
NMA1982 is a Novel Phosphatase and Potential Virulence Factor in Neisseria meningitidis.
bioRxiv
; 2023 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37292688
11.
Enzyme Mechanistic Studies of NMA1982, a Protein Tyrosine Phosphatase and Potential Virulence Factor in Neisseria meningitidis.
Res Sq
; 2023 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37693380
12.
Detection of Cellular Target Engagement for Small-Molecule Modulators of Striatal-Enriched Protein Tyrosine Phosphatase (STEP).
Methods Mol Biol
; 2706: 167-175, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37558948
13.
Protein Tyrosine Phosphatase Biochemical Inhibition Assays.
Bio Protoc
; 12(18)2022 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36248604
14.
Distinct functional and conformational states of the human lymphoid tyrosine phosphatase catalytic domain can be targeted by choice of the inhibitor chemotype.
J Comput Aided Mol Des
; 25(9): 873-83, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21904909
15.
A highly convergent synthesis of myristoyl-carba(dethia)-coenzyme A.
European J Org Chem
; 2010(9): 1728-1735, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22347809
16.
Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors.
J Vis Exp
; (161)2020 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32744526
17.
Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer.
J Med Chem
; 63(23): 14609-14625, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33200929
18.
Lipid raft targeting of hematopoietic protein tyrosine phosphatase by protein kinase C theta-mediated phosphorylation.
Mol Cell Biol
; 26(5): 1806-16, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16479000
19.
TCR-induced downregulation of protein tyrosine phosphatase PEST augments secondary T cell responses.
Mol Immunol
; 45(11): 3074-84, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18457880
20.
The lipid-binding SEC14 domain.
Biochim Biophys Acta
; 1771(6): 719-26, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17428729