Detalhe da pesquisa
1.
Rare disease variant curation from literature: assessing gaps with creatine transport deficiency in focus.
BMC Genomics
; 24(1): 460, 2023 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37587458
2.
Transcriptomic profiling in canines and humans reveals cancer specific gene modules and biological mechanisms common to both species.
PLoS Comput Biol
; 17(9): e1009450, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34570764
3.
Benserazide racemate and enantiomers induce fetal globin gene expression in vivo: Studies to guide clinical development for beta thalassemia and sickle cell disease.
Blood Cells Mol Dis
; 89: 102561, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33744514
4.
Pharmacological clearance of misfolded rhodopsin for the treatment of RHO-associated retinitis pigmentosa.
FASEB J
; 34(8): 10146-10167, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32536017
5.
Canine meningiomas are comprised of 3 DNA methylation groups that resemble the molecular characteristics of human meningiomas.
Acta Neuropathol
; 147(1): 43, 2024 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38376604
6.
Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors.
Bioorg Med Chem Lett
; 28(20): 3356-3362, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30227946
7.
Novel lead structures with both Plasmodium falciparum gametocytocidal and asexual blood stage activity identified from high throughput compound screening.
Malar J
; 16(1): 147, 2017 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28407766
8.
A systems biology strategy to identify molecular mechanisms of action and protein indicators of traumatic brain injury.
J Neurosci Res
; 93(2): 199-214, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25399920
9.
Exploiting large-scale drug-protein interaction information for computational drug repurposing.
BMC Bioinformatics
; 15: 210, 2014 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-24950817
10.
Synthesis and evaluation of Strychnos alkaloids as MDR reversal agents for cancer cell eradication.
Bioorg Med Chem
; 22(3): 1148-55, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24405813
11.
Quatramer™ encapsulation of dual-targeted PI3-Kδ/HDAC6 inhibitor, HSB-510, suppresses growth of breast cancer.
Bioeng Transl Med
; 8(5): e10541, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-37693068
12.
Transcriptional profiling of canine osteosarcoma identifies prognostic gene expression signatures with translational value for humans.
Commun Biol
; 6(1): 856, 2023 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37591946
13.
Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects.
Elife
; 122023 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36975211
14.
Locally weighted learning methods for predicting dose-dependent toxicity with application to the human maximum recommended daily dose.
Chem Res Toxicol
; 25(10): 2216-26, 2012 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22963722
15.
QSAR classification model for antibacterial compounds and its use in virtual screening.
J Chem Inf Model
; 52(10): 2559-69, 2012 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23013546
16.
Exploring polypharmacology using a ROCS-based target fishing approach.
J Chem Inf Model
; 52(2): 492-505, 2012 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22196353
17.
Rottlerin inhibits La Crosse virus-induced encephalitis in mice and blocks release of replicating virus from the Golgi body in neurons.
Nat Microbiol
; 6(11): 1398-1409, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34675384
18.
Modeling G protein-coupled receptors for structure-based drug discovery using low-frequency normal modes for refinement of homology models: application to H3 antagonists.
Proteins
; 78(2): 457-73, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19787776
19.
Identification of a new class of small molecule C5a receptor antagonists.
Bioorg Med Chem Lett
; 20(2): 662-4, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20004096
20.
Benzimidazole- and indole-substituted 1,3'-bipyrrolidine benzamides as histamine H3 receptor antagonists.
Bioorg Med Chem Lett
; 20(3): 1237-40, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20042333