Detalhe da pesquisa
1.
Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing.
PLoS Genet
; 10(9): e1004620, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25232829
2.
Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutations.
PLoS Genet
; 8(11): e1003082, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23166522
3.
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease.
Nat Genet
; 38(5): 515-7, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16604074
4.
Production of transmitochondrial cybrids containing naturally occurring pathogenic mtDNA variants.
Nucleic Acids Res
; 34(13): e95, 2006 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-16885236
5.
Mitochondrial DNA mutations in human colonic crypt stem cells.
J Clin Invest
; 112(9): 1351-60, 2003 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-14597761
6.
Investigation of the mitochondrial genome in patients with atypical motor neuron disease.
J Neurol
; 254(4): 482-7, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17401521
7.
Mitochondrial DNA mutations in individuals occupationally exposed to ionizing radiation.
Radiat Res
; 165(2): 202-7, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16435918
8.
Defining the importance of mitochondrial gene defects in maternally inherited diabetes by sequencing the entire mitochondrial genome.
Diabetes
; 51(7): 2317-20, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12086967
9.
Somatic mitochondrial DNA deletions accumulate to high levels in aging human extraocular muscles.
Invest Ophthalmol Vis Sci
; 51(7): 3347-53, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20164450
10.
Quantification of mitochondrial DNA mutation load.
Aging Cell
; 8(5): 566-72, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19624578
11.
Motor neuron disease in a patient with a mitochondrial tRNAIle mutation.
Ann Neurol
; 59(3): 570-4, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16358336
12.
Genotypes from patients indicate no paternal mitochondrial DNA contribution.
Ann Neurol
; 54(4): 521-4, 2003 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-14520666