1.
Inorg Chem Commun
; 64: 45-49, 2016 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26752972
RESUMO
A novel complex, [Cu(acetylethTSC)Cl]Clâ¢0.25C2H5OH 1 (where acetylethTSC = (E)-N-ethyl-2-[1-(thiazol-2-yl)ethylidene]hydrazinecarbothioamide), was shown to have anti-proliferative activity against various colon and aggressive breast cancer cell lines. In vitro studies showed that complex 1 acted as a poison inhibitor of human topoisomerase IIα, which may account for the observed anti-cancer effects.