Detalhe da pesquisa
1.
Inducing and exploiting vulnerabilities for the treatment of liver cancer.
Nature
; 574(7777): 268-272, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31578521
2.
Unexpected moves: a conformational change in MutSα enables high-affinity DNA mismatch binding.
Nucleic Acids Res
; 51(3): 1173-1188, 2023 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36715327
3.
Extensive trimming of short single-stranded DNA oligonucleotides during replication-coupled gene editing in mammalian cells.
PLoS Genet
; 16(10): e1009041, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33119594
4.
Three-step site-directed mutagenesis screen identifies pathogenic MLH1 variants associated with Lynch syndrome.
J Med Genet
; 57(5): 308-315, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31784484
5.
DNA mismatch repair and oligonucleotide end-protection promote base-pair substitution distal from a CRISPR/Cas9-induced DNA break.
Nucleic Acids Res
; 46(6): 2945-2955, 2018 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29447381
6.
Suspected Lynch syndrome associated MSH6 variants: A functional assay to determine their pathogenicity.
PLoS Genet
; 13(5): e1006765, 2017 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-28531214
7.
Oligonucleotide-directed mutagenesis screen to identify pathogenic Lynch syndrome-associated MSH2 DNA mismatch repair gene variants.
Proc Natl Acad Sci U S A
; 113(15): 4128-33, 2016 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26951660
8.
LNA modification of single-stranded DNA oligonucleotides allows subtle gene modification in mismatch-repair-proficient cells.
Proc Natl Acad Sci U S A
; 113(15): 4122-7, 2016 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26951689
9.
Double somatic mutations in mismatch repair genes are frequent in colorectal cancer after Hodgkin's lymphoma treatment.
Gut
; 67(3): 447-455, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29439113
10.
Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling.
Genes Dev
; 24(13): 1377-88, 2010 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20551164
11.
Genomic landscape of retinoblastoma in Rb-/- p130-/- mice resembles human retinoblastoma.
Genes Chromosomes Cancer
; 56(3): 231-242, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27750399
12.
Colorectal cancer surveillance in Hodgkin lymphoma survivors at increased risk of therapy-related colorectal cancer: study design.
BMC Cancer
; 17(1): 112, 2017 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28173773
13.
SPO11-independent DNA repair foci and their role in meiotic silencing.
PLoS Genet
; 9(6): e1003538, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23754961
14.
Temozolomide increases the number of mismatch repair-deficient intestinal crypts and accelerates tumorigenesis in a mouse model of Lynch syndrome.
Gastroenterology
; 147(5): 1064-72.e5, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25088490
15.
Functional analysis of MSH2 unclassified variants found in suspected Lynch syndrome patients reveals pathogenicity due to attenuated mismatch repair.
J Med Genet
; 51(4): 245-53, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24501230
16.
Paradoxical activation of oncogenic signaling as a cancer treatment strategy.
Cancer Discov
; 2024 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38533987
17.
Fancf-deficient mice are prone to develop ovarian tumours.
J Pathol
; 226(1): 28-39, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21915857
18.
Mitogen requirement for cell cycle progression in the absence of pocket protein activity.
Cancer Cell
; 8(6): 455-66, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16338659
19.
Genome-wide siRNA screens identify RBBP9 function as a potential target in Fanconi anaemia-deficient head-and-neck squamous cell carcinoma.
Commun Biol
; 6(1): 37, 2023 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36639418
20.
The mismatch repair system protects against intergenerational GAA repeat instability in a Friedreich ataxia mouse model.
Neurobiol Dis
; 46(1): 165-71, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22289650