[Evaluation of hydroalcoholic extract of Aroeira (Shinus Terebinthifolius Raddi) in the healing process of wound skin in rats]. / Avaliação do extrato hidroalcoólico de Aroeira (Schinus terebinthifolius Raddi) no processo de cicatrização de feridas em pele de ratos.

PURPOSE: To evaluate the healing effect of the topic administration of the hydroalcoholic extract of aroeira in open wounds in the dorsocostal region of rats. METHODS: Sixty Wistar rats, males, were used. In all animals one skin fragment was removed, with two centimeters in diameter. Inhalatory anesthesia with ethyl ether was done, The rats were divided in two groups of 30 animals: aroeira group, submitted to an topic application of the hydroalcoholic extract of the plant, and control group, with the same process but with 0.9% saline solution. Each group was divided in three sub-groups of 10 animals according to the period of observation: 7, 14 and 21 days. The areas of the injuries were analyzed by the macroscopic aspect and digital planimetry, and the resected segments of the wounds were studied by optic microscopy stained with hematoxilin-eosine and trichromium of Masson. RESULTS: The macroscopic findings showed early complete reepitelization in the control group by the 14th day. According to the digital planimetry the average wound areas of the rats from the control group (0.5278 cm(2)) had been smaller than those from the wounds of the rats of the aroeira group (0.6897 cm(2)), with statistical significance to the 14th day (p=0.036). The histologic study showed statistical difference (p=0.023) regarding the mononuclear cells in 14th day of evaluation, with larger number in the aroeira group, without significant differences regarding other parameters in all the remaining days. CONCLUSION: The topic use of the hydroalcoholic extract of aroeira delayed the reepitelization of the skin wounds in rats.

Perfil epidemiológico, achados endoscópicos e controle de qualidade das colonoscopias realizadas em uma clínica de gastroenterologia do município de Criciúma entre março e setembro de 2009 / Epidemiological profile, endoscopic findings and quality control of colonoscopies performed in a gastroenterology clinic in the city of Criciúma in the period between march and september 2009

Objetivo: descrever os achados endoscópicos e sua correlação epidemiológica, o índice de acesso ao ceco e a taxa de detecção de adenomas como descritores da finalidade dos exames praticados em uma clínica privada de Criciúma, SC. Métodos: foram analisados os laudos das colonoscopias realizadas na rotina de uma clínica de gastroenterologia, entre março e setembro de 2009, levando em consideração a faixa etária, o sexo, a raça, os achados endoscópicos, as indicações para a realização da colonoscopia, a qualidade do preparo intestinal e o índice de acesso ao ceco. Elaborou-se um estudo retrospectivo, do tipo descritivo, transversal e documental de abordagem quantitativa e qualitativa. Resultados: dos 303 exames incluídos no estudo, 198 pacientes eram do sexo feminino (65,3%) e a média de idade foi de 53,7 anos (12 a 86 anos). As indicações para a realização do exame foram: alteração do ritmo intestinal 92 (30,4%), sangramento intestinal 78 (25,7%) e dor abdominal 56 (18,5%). O índice de acesso ao ceco foi de 96,6%, detectou-se adenoma em 43,9% e neoplasia avançada em 3,4%. Conclusão: houve aumento da frequência de neoplasias (câncer avançado e pólipos) com o aumento da idade, com maior prevalência no sexo masculino. O índice de acesso ao ceco e a taxa de detecção de adenomas encontram-se de acordo com a literatura pesquisada.

Objective: to describe the endoscopic and their epidemiological correlation, the index of access to the cecum and the detection rate of adenomas as descriptors of the purpose of examinations performed in a private clinic of Criciuma - SC. Methods: we analyzed reports of colonoscopies performed in the routine of a gastroenterology clinic between March and June 2009, taking into account age, sex, race, endoscopic findings, the indications for colonoscopy, the preparation intestinal content and access to the cecum. Was conducted a retrospective, descriptive, transversal and documentation of quantitative and qualitative approach. Results: of 303 surveys included in the study 198 patients were female (65.3%) and the mean age was 53.7 years (12-86 years). The indications for the exam were: change of pace intestinal 92 (30.4%), intestinal bleeding 78 (25.7%) and abdominal pain 56 (18.5%). The index of access to the cecum was 96.6%, was detected in 43.9% adenoma and advanced neoplasia in 3.4%. Conclusion: increased frequency of neoplasms (cancer and advanced polyps) with increasing age, with higher prevalence in males. The index of access to the cecum and the detection rate of adenomas are in agreement with the literature.

Avaliação do extrato hidroalcoólico de Aroeira (Schinus terebinthifolius Raddi) no processo de cicatrização de feridas em pele de ratos / Evaluation of hydroalcoholic extract of Aroeira (Shinus Terebinthifolius Raddi) in the healing process of wound skin in rats

OBJETIVO: Avaliar o efeito cicatrizante da administração tópica do extrato hidroalcoólico de aroeira em feridas abertas na região dorsocostal de ratos. MÉTODOS: Utilizou-se 60 ratos Wistar, machos, que tiveram retirado fragmentos de pele com dois centímetros de diâmetro, sob anestesia inalatória com éter etílico. Foram divididos em dois grupos de 30 animais: o grupo aroeira, que recebeu aplicação do extrato hidroalcoólico da planta, e o grupo controle, que recebeu aplicação de solução salina a 0,9 por cento. Cada grupo foi subdividido em 3 com 10 animais cada para serem observados aos sete, 14 ou 21 dias. As áreas das lesões foram analisadas pelo aspecto macroscópico e por planimetria digital. Os espécimes ressecados das feridas foram analisados por microscopia ótica em colorações de hematoxilina-eosina e tricrômio de Masson. RESULTADOS: Os achados macroscópicos demonstraram reepitelização completa mais precoce no grupo controle aos 14 dias. Pela planimetria digital as áreas médias das feridas dos ratos do grupo controle (0,5278 cm²) foram menores que as das feridas dos ratos do grupo aroeira (0,6897 cm²), com significância estatística aos 14 dias de pós-operatório (p=0,036). O estudo histológico demonstrou diferença estatística (p=0,023) em relação às células mononucleares no 14° dia de avaliação, com maior número no grupo aroeira, não havendo diferenças significantes em relação aos outros parâmetros em nenhum dos dias estudados. CONCLUSÃO: O extrato hidroalcoólico de aroeira retardou a reepitelização das feridas da pele dos ratos.

PURPOSE: To evaluate the healing effect of the topic administration of the hydroalcoholic extract of aroeira in open wounds in the dorsocostal region of rats. METHODS: Sixty Wistar rats, males, were used. In all animals one skin fragment was removed, with two centimeters in diameter. Inhalatory anesthesia with ethyl ether was done, The rats were divided in two groups of 30 animals: aroeira group, submitted to an topic application of the hydralcoholic extract of the plant, and control group, with the same process but with 0.9 percent saline solution. Each group was divided in three sub-groups of 10 animals according to the period of observation: 7, 14 and 21 days. The areas of the injuries were analyzed by the macrocospic aspect and digital planimetry, and the resected segments of the wounds were studied by optic microscopy stainned with hematoxilin-eosine and trichromium of Masson. RESULTS: The macrocospic findings showed early complete reepitelization in the control group by the 14th day. According to the digital planimetry the average wound areas of the rats from the control group (0.5278 cm²) had been smaller than those from the wounds of the rats of the aroeira group (0.6897 cm²), with statistical significance to the 14th day (p=0.036). The hystologic study showed statistical difference (p=0.023) regarding the mononuclear cells in 14th day of evaluation, with larger number in the aroeira group, without significant differences regarding other parameters in all the remaining days. CONCLUSION: The topic use of the hydralcoholic extract of aroeira delayed the reepitelization of the skin wounds in rats.