Detalhe da pesquisa
1.
Discovery of a novel small molecule agonist scaffold for the APJ receptor.
Bioorg Med Chem
; 24(16): 3758-70, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27369451
2.
Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of replacement of the 3-hydroxyphenyl group with pyridine or thiophene bioisosteres.
Bioorg Med Chem
; 24(16): 3842-8, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27364611
3.
The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2.
Bioorg Med Chem Lett
; 25(10): 2060-4, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25881832
4.
Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2.
Bioorg Med Chem Lett
; 25(2): 292-6, 2015 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25499438
5.
Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of the 3- and 4-methyl substituents.
Bioorg Med Chem
; 23(19): 6379-88, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26342544
6.
Imidazole-derived agonists for the neurotensin 1 receptor.
Bioorg Med Chem Lett
; 24(1): 262-7, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24332089
7.
Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives.
Bioorg Med Chem Lett
; 20(22): 6812-5, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20855211
8.
Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain.
Bioorg Med Chem
; 18(22): 7816-25, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20965738
9.
The identification of nonpeptide neurotensin receptor partial agonists from the potent antagonist SR48692 using a calcium mobilization assay.
Bioorg Med Chem Lett
; 19(5): 1438-41, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19195889
10.
The effect of kappa-opioid receptor agonists on tetrodotoxin-resistant sodium channels in primary sensory neurons.
Anesth Analg
; 109(2): 632-40, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19608841
11.
Synthesis and in vitro opioid receptor functional antagonism of analogues of the selective kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic).
J Med Chem
; 51(6): 1849-60, 2008 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-18307295
12.
Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.
J Med Chem
; 51(3): 407-16, 2008 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18176998
13.
A new synthesis of the ORL-1 antagonist 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397) and activity in a calcium mobilization assay.
Bioorg Med Chem
; 16(2): 822-9, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17976996
14.
Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain.
Bioorg Med Chem
; 16(12): 6379-86, 2008 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18501613
15.
Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3 R)- N-[1 R)-1-(Cyclohexylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (CDTic).
J Med Chem
; 61(17): 7546-7559, 2018 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30032602
16.
Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3 R)-7-Hydroxy- N-[(1 S)-2-methyl-1-(piperidin-1-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (PDTic).
J Med Chem
; 61(17): 7525-7545, 2018 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30117738
17.
Anxiolytic-like effects of kappa-opioid receptor antagonists in models of unlearned and learned fear in rats.
J Pharmacol Exp Ther
; 323(3): 838-45, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17823306
18.
Simple Tetrahydroisoquinolines Are Potent and Selective Kappa Opioid Receptor Antagonists.
ACS Med Chem Lett
; 8(7): 742-745, 2017 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28740609
19.
Highly potent and selective phenylmorphan-based inverse agonists of the opioid delta receptor.
J Med Chem
; 49(18): 5597-609, 2006 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-16942033
20.
N-substituted 4beta-methyl-5-(3-hydroxyphenyl)-7alpha-amidomorphans are potent, selective kappa opioid receptor antagonists.
J Med Chem
; 49(5): 1781-91, 2006 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16509593