Detalhe da pesquisa
1.
Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
J Biol Chem
; 296: 100568, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33753169
2.
Development of a chemical probe against NUDT15.
Nat Chem Biol
; 16(10): 1120-1128, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32690945
3.
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1: Triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines.
Bioorg Med Chem Lett
; 27(16): 3897-3904, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28687206
4.
Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction.
Org Biomol Chem
; 15(37): 7758-7764, 2017 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28891572
5.
Intramolecular thermal stepwise [2 + 2] cycloadditions: investigation of a stereoselective synthesis of [n.2.0]-bicyclolactones.
Org Biomol Chem
; 14(40): 9554-9559, 2016 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27722445
6.
Synthesis and Biological Evaluation of Cyclobutane-Based ß3 Integrin Antagonists: A Novel Approach to Targeting Integrins for Cancer Therapy.
Cancers (Basel)
; 15(16)2023 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37627051
7.
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir.
Cell Chem Biol
; 28(12): 1693-1702.e6, 2021 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34192523
8.
Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold.
Structure
; 26(2): 295-303.e6, 2018 02 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29413322