Detalhe da pesquisa
1.
An Alternative Focus for Route Design for the Synthesis of Antibody-Drug Conjugate Payloads.
J Org Chem
; 84(8): 4830-4836, 2019 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30602115
2.
Synthesis and in vitro evaluation of SG3227, a pyrrolobenzodiazepine dimer antibody-drug conjugate payload based on sibiromycin.
Bioorg Med Chem Lett
; 27(5): 1154-1158, 2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28188066
3.
A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology.
Bioconjug Chem
; 24(7): 1256-63, 2013 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-23808985
4.
Comparison of Pyrrolobenzodiazepine Dimer Bis-imine versus Mono-imine: DNA Interstrand Cross-linking, Cytotoxicity, Antibody-Drug Conjugate Efficacy and Toxicity.
Mol Cancer Ther
; 22(2): 254-263, 2023 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36722141
5.
Preclinical Characterization of an Antibody-Drug Conjugate Targeting CS-1 and the Identification of Uncharacterized Populations of CS-1-Positive Cells.
Mol Cancer Ther
; 19(8): 1649-1659, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32404408
6.
Synthesis of a novel C2/C2'-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate.
Bioorg Med Chem Lett
; 19(22): 6463-6, 2009 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19811912
7.
An asymmetric C8/C8'-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs.
Bioorg Med Chem Lett
; 18(6): 2073-7, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18272367
8.
SLC46A3 as a Potential Predictive Biomarker for Antibody-Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads.
Clin Cancer Res
; 24(24): 6570-6582, 2018 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30131388
9.
Pyrrolobenzodiazepine Antibody-Drug Conjugates Designed for Stable Thiol Conjugation.
Antibodies (Basel)
; 6(4)2017 Nov 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31548535
10.
Design and Synthesis of Tesirine, a Clinical Antibody-Drug Conjugate Pyrrolobenzodiazepine Dimer Payload.
ACS Med Chem Lett
; 7(11): 983-987, 2016 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27882195
11.
SG2285, a novel C2-aryl-substituted pyrrolobenzodiazepine dimer prodrug that cross-links DNA and exerts highly potent antitumor activity.
Cancer Res
; 70(17): 6849-58, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20660714
12.
Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents.
J Med Chem
; 53(7): 2927-41, 2010 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20218628
13.
Application of the Stille coupling reaction to the synthesis of C2-substituted endo-exo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs).
Bioorg Med Chem Lett
; 14(20): 5041-4, 2004 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-15380195