Detalhe da pesquisa
1.
Dose selection for a phase III study evaluating gepotidacin (GSK2140944) in the treatment of uncomplicated urogenital gonorrhoea.
Sex Transm Infect
; 99(1): 64-69, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36411033
2.
Pharmacokinetics of Oral Formulations of Gepotidacin (GSK2140944), a Triazaacenaphthylene Bacterial Type II Topoisomerase Inhibitor, in Healthy Adult and Adolescent Participants.
Antimicrob Agents Chemother
; 66(1): e0126321, 2022 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34633853
3.
Dose Selection for Phase III Clinical Evaluation of Gepotidacin (GSK2140944) in the Treatment of Uncomplicated Urinary Tract Infections.
Antimicrob Agents Chemother
; 66(3): e0149221, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34978887
4.
Comparison between physiologically based pharmacokinetic and population pharmacokinetic modelling to select paediatric doses of gepotidacin in plague.
Br J Clin Pharmacol
; 88(2): 416-428, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34289143
5.
Phase 2a Pharmacokinetic, Safety, and Exploratory Efficacy Evaluation of Oral Gepotidacin (GSK2140944) in Female Participants with Uncomplicated Urinary Tract Infection (Acute Uncomplicated Cystitis).
Antimicrob Agents Chemother
; 64(7)2020 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32284384
6.
In Vitro Activity and Microbiological Efficacy of Gepotidacin from a Phase 2, Randomized, Multicenter, Dose-Ranging Study in Patients with Acute Bacterial Skin and Skin Structure Infections.
Antimicrob Agents Chemother
; 64(3)2020 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31818823
7.
Gepotidacin for the Treatment of Uncomplicated Urogenital Gonorrhea: A Phase 2, Randomized, Dose-Ranging, Single-Oral Dose Evaluation.
Clin Infect Dis
; 67(4): 504-512, 2018 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29617982
8.
Microbiological Analysis from a Phase 2 Randomized Study in Adults Evaluating Single Oral Doses of Gepotidacin in the Treatment of Uncomplicated Urogenital Gonorrhea Caused by Neisseria gonorrhoeae.
Antimicrob Agents Chemother
; 62(12)2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30249694
9.
A Phase I, Randomized, Double-Blinded, Placebo- and Moxifloxacin-Controlled, Four-Period Crossover Study To Evaluate the Effect of Gepotidacin on Cardiac Conduction as Assessed by 12-Lead Electrocardiogram in Healthy Volunteers.
Antimicrob Agents Chemother
; 61(5)2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28223381
10.
Efficacy, Safety, and Tolerability of Gepotidacin (GSK2140944) in the Treatment of Patients with Suspected or Confirmed Gram-Positive Acute Bacterial Skin and Skin Structure Infections.
Antimicrob Agents Chemother
; 61(6)2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28373199
11.
The metabolism and disposition of GSK2140944 in healthy human subjects.
Xenobiotica
; 46(8): 683-702, 2016 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26586303
12.
Pharmacokinetics, safety, and tolerability of gepotidacin administered as single or repeat ascending doses, in healthy adults and elderly subjects.
Clin Transl Sci
; 15(9): 2251-2264, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35769034
13.
Design of Two Phase III, Randomized, Multicenter Studies Comparing Gepotidacin with Nitrofurantoin for the Treatment of Uncomplicated Urinary Tract Infection in Female Participants.
Infect Dis Ther
; 11(6): 2297-2310, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36271314
14.
Pharmacokinetics of Gepotidacin in Subjects With Normal Hepatic Function and Hepatic Impairment.
Clin Pharmacol Drug Dev
; 10(6): 588-597, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33450142
15.
Pharmacokinetics of Gepotidacin in Renal Impairment.
Clin Pharmacol Drug Dev
; 9(5): 560-572, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32429000
16.
Pharmacokinetics, Safety, and Tolerability Evaluation of Single and Multiple Doses of GSK3342830 in Healthy Volunteers.
Clin Pharmacol Drug Dev
; 8(6): 754-764, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30536589