1.
J Pharm Sci
; 66(6): 834-7, 1977 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-874785
RESUMO
Sensitive and specific assays are described for the quantitation of mefloquine in whole blood, plasma, and urine specimens using high-pressure liquid chromatography. Specimens were extracted with ethyl acetate and concentrated before chromatography. Whole blood and plasma extracts were chromatographed on a polar bonded phase partitioning column, and urine extracts were chromatographed on a bonded reversed-phase partitioning column. The sensitivity of the assays for mefloquine was 0.05 microgram/ml of whole blood or plasma and 0.25 microgram/ml of urine using 5-ml samples. The assays are suitable for studying mefloquine pharmacokinetics in humans.