Detalhe da pesquisa
1.
Activity and Expression of Carboxylesterases and Arylacetamide Deacetylase in Human Ocular Tissues.
Drug Metab Dispos
; 50(12): 1483-1492, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36195336
2.
Carboxylesterase Activities and Protein Expression in Rabbit and Pig Ocular Tissues.
Mol Pharm
; 18(3): 1305-1316, 2021 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33595329
3.
Tandem mass spectrometric analysis of S- and N-linked glutathione conjugates of pulegone and menthofuran and identification of P450 enzymes mediating their formation.
Rapid Commun Mass Spectrom
; 30(7): 917-26, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26969934
4.
Bridged Epipolythiodiketopiperazines from Penicillium raciborskii, an Endophytic Fungus of Rhododendron tomentosum Harmaja.
J Nat Prod
; 79(4): 685-90, 2016 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27057690
5.
Toxicity of Carboxylic Acid-Containing Drugs: The Role of Acyl Migration and CoA Conjugation Investigated.
Chem Res Toxicol
; 28(12): 2292-303, 2015 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26558897
6.
Glutathione trapping of reactive drug metabolites produced by biomimetic metalloporphyrin catalysts.
Rapid Commun Mass Spectrom
; 29(6): 521-32, 2015 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-26160418
7.
Effects of cytochrome P450 inhibitors and inducers on the metabolism and pharmacokinetics of ospemifene.
Biopharm Drug Dispos
; 34(7): 387-95, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23852652
8.
Extrahepatic in vitro metabolism of peptides; comparison of human kidney and intestinal S9 fraction, human plasma and proximal tubule cells, using cyclosporine A, leuprorelin, and cetrorelix as model compounds.
J Pharm Biomed Anal
; 225: 115219, 2023 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36630767
9.
Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues.
Eur J Pharm Sci
; 191: 106603, 2023 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37827455
10.
Effects of cell differentiation and assay conditions on the UDP-glucuronosyltransferase activity in Caco-2 cells.
Drug Metab Dispos
; 39(3): 456-64, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21098645
11.
Characterization of cyanide-trapped methylated metabonates formed during reactive drug metabolite screening in vitro.
Rapid Commun Mass Spectrom
; 25(10): 1382-90, 2011 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-21504003
12.
Hepatic in vitro metabolism of peptides; Comparison of human liver S9, hepatocytes and Upcyte hepatocytes with cyclosporine A, leuprorelin, desmopressin and cetrorelix as model compounds.
J Pharm Biomed Anal
; 196: 113921, 2021 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33548873
13.
Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2-mediated mechanism.
Br J Pharmacol
; 178(12): 2461-2481, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33687065
14.
Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells.
Drug Metab Dispos
; 38(3): 516-25, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20019244
15.
Glutathione trapping of reactive drug metabolites produced by biomimetic metalloporphyrin catalysts.
Rapid Commun Mass Spectrom
; 29(19): 1849-50, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26331937
16.
Comparison of triple quadrupole, hybrid linear ion trap triple quadrupole, time-of-flight and LTQ-Orbitrap mass spectrometers in drug discovery phase metabolite screening and identification in vitro--amitriptyline and verapamil as model compounds.
Rapid Commun Mass Spectrom
; 24(7): 939-57, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20209667
17.
4ß-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters.
Front Pharmacol
; 11: 361, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32292343
18.
Functional expression, inhibition and induction of CYP enzymes in HepaRG cells.
Toxicol In Vitro
; 23(4): 748-53, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19328226
19.
Potential inhibition of major human cytochrome P450 isoenzymes by selected tropical medicinal herbs-Implication for herb-drug interactions.
Food Sci Nutr
; 7(1): 44-55, 2019 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-30680158
20.
In vitro modulation of cytochrome P450 isozymes and pharmacokinetics of caffeine by extracts of Hibiscus sabdariffa Linn calyx.
J Basic Clin Physiol Pharmacol
; 30(3)2019 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30951501