RESUMO
The karyotype of a cystic partially differentiated nephroblastoma (CPDN) was found to be 51, XY, +7, +8, +12, +13, +17. A review of the literature disclosed three other cytogenetically analyzed CPDNs. As in this case, they were all hyperdiploid. The only chromosomal anomaly common to all four cases was trisomy 12, suggesting this chromosome might have a pathogenetic role. Earlier reports had tentatively attributed this role to chromosome 8.
Assuntos
Cromossomos Humanos Par 12 , Diploide , Doenças Renais Císticas/patologia , Neoplasias Renais/patologia , Trissomia , Tumor de Wilms/patologia , Diferenciação Celular , Humanos , Lactente , Doenças Renais Císticas/genética , Neoplasias Renais/genética , Masculino , Tumor de Wilms/genéticaRESUMO
We report the cytogenetic analysis of a choroid plexus papilloma, a benign tumor, with a modal number of 56 chromosomes. In our review of the few reported karyotypes of choroid plexus tumors, we found no predictive relationship between the karyotype and the pathologic diagnosis or outcome.
Assuntos
Neoplasias do Plexo Corióideo/genética , Glioma/genética , Neoplasias do Plexo Corióideo/patologia , Glioma/patologia , Humanos , Lactente , Cariotipagem , Imageamento por Ressonância Magnética , MasculinoRESUMO
Hepatosplenic gamma-delta (gammadelta) T-cell lymphoma is a rare but increasingly recognized lymphoid malignancy predominantly affecting young adult males. It is not well appreciated in the pediatric population. We report the third case of this aggressive lymphoma in a child as well as additional support for the consistency of the recently discovered cytogenetic abnormalities, isochromosome 7q and trisomy 8, which in this case were documented using fluorescence in situ hybridization (FISH) of a touch-preparation of the spleen.