Analysis and interpretation of Coronavirus infection children's incidence, contributing factors, risks of complications and their relationship.

OBJECTIVE: Aim: To study and investigate the incidence of Coronavirus infection in children, the course of the disease, the risks of complications and their interrelationships. PATIENTS AND METHODS: Materials and Methods: Study included the analysis and observation of children (n=55, aged 14.36±3.62 years) with confirmed Coronerovirus infection, who were observed in the CNE ≪CMCH≫ in Uzhgorod in outpatient conditions. A study of clinical presentations, a clinical and laboratory examination followed by a mathematical analysis of the symptoms data in children with an identified Coronavirus infection and in the dynamics up to week 30 (with survey intervals in 3 weeks) from the diagnosis verification was carried out. RESULTS: Results: A dynamic analysis of the clinical manifestation of symptoms in children with an identified Corona virus infection and within 30 weeks (with survey intervals of 3 weeks) from the beginning of the diagnosis verification was carried out. Complaints from the respiratory system were prevailed. The most long-lasting complaint was observed ≪changes in the sense of taste and smell≫ (from 35(63.6%) to 6(10.9%) up to 18 weeks inclusive. Other complaints ≪Cough, Rhinitis, Shortness of breath, Pain in the chest≫ was observed for 6 weeks. Sore throat, muscular and joint pain were persisted for 3 weeks. Fever was not identified at week 3. Illness with other viral respiratory diseases started at week 9 and was observed until week 30 (from 10(18.2%) to 19(34.5%)) with varying levels. A decrease in cases of IgM identification was observed within 6 weeks (from 55, 100% to 20, 36, 4%). On the 9th week, the presence of IgM was not established. There is also an increase in the number of cases of detection of IgG in patients with a level maximum of 6 weeks. CONCLUSION: Conclusions: There is a positive effect of the CRP level on the occurrence of symptoms of cough, rhinitis, shortness of breath, chest pain, change in taste and smell, muscle and joint pain (r=0.33-0.55), with the most significant data for the symptom of pain in chest (p=0.00001). Ferritin level interactions mostly had a negative direction (r=-0.35-0.48, p=0.02-0.00001) on the development of symptoms, with the exception of rhinorrhea (r=0.48, p=0.00002) and chest pains (r=0.39, 0.003). According to multiple logistic regression analysis the chance of the symptom of a change in taste and smell increases due to an increasing in the level of Procalcitonin in 1.48 times. The chance of the symptom of shortness of breath increased due to an increasing in the Ferritin level in 1.025 times.

RESPIRATORY MICROBIOME AND ITS RELATIONSHIP WITH INFLAMMATORY MARKERS.

OBJECTIVE: The aim: This study aims to investigate and analyze the microbiome of the nasopharyngeal zone in acute respiratory infections (ARI) and their relationship with inflammatory markers. PATIENTS AND METHODS: Materials and methods: Examination of 112 children (10-14 years old) with acute respiratory infections (ARI) of the upper respiratory tract was carried out. The control group consisted of 25 healthy children identical in age and examination parameters. RESULTS: Results: When analyzing the microflora of the nasopharynx of patients, 29,0% of strains were gram-positive bacteria and 71,0% were gram-negative bacteria (Escherichia coli representing 37,0%). Biochemical examination of the biomaterial revealed the presence of sucrase (n=69), maltase (n=87), lactorepoxidase (n-89) and alcohols - sorbitol (hexahydric alcohol, n=102), mannitol (hexahydric alcohol, n=84), xylitol (pentahydric alcohol, n=86). Regarding the markers of inflammatory response, the following dynamics was noted: increase in the level of IgM (3,91 ± 1,79 g/l, p<0,01) by 2,2 times, elevation of Ig G level by 10 times (145, 91 ± 53,04 g/l, p< 0,01), slightly higher than the reference values IgE level. In addition, increased IL-1, IL-4, IL-6, γ-IFN, TNF-α, Neopterin levels were detected. The level of Thyroid stimulating hormone (TSH) was significantly different compared to the control group (0,62 ± 0,57 vs. 1,98 ± 0,30 mIU/ ml, p< 0,01), but within the reference values. CONCLUSION: Conclusions: Predominance of Gram-negative bacteria in the nasopharyngeal microflora of patients along with elevated inflammatory markers and lactop-eroxydase enzyme predominance was detected in the study.

Syndromal characteristics of the combined course of chronic pancreatitis and arterial hypertension.

OBJECTIVE: The aim:To study the clinical course of chronic pancreatitis (CP) in patients with concomitant hypertension. PATIENTS AND METHODS: Materials and methods: A thorough analysis of the results of subjective and clinical and laboratory examinations of 102 patients with CP, who were hospitalized in the therapeutic department of Khust district hospital during 2017-2018 was conducted. RESULTS: Results: Takingintoaccount that the initial examination of patients was carried out during the period of exacerbation of the disease, all patients presentedwith pain syndrome (100%).The overwhelming majority of patients identified pain as permanent aching discomfort in the abdominal cavity with periodic intensification (n = 41 (40,2%), 18 patients indicated burning pain (17,6%), 30 - cutting (29,4%) ), and 13 (12,7%) experienced pain of varying nature.due to the presence of hypertension (GC) 73 (71.6%) patients complained of a headache of a paroxysmal periodic pulsating character, which was most often localized in the occipital-frontal area and was accompanied by dizziness, "flickering of flies" before the eyes, noise in the ears. Also, 14 (13,7%) patients had shortness of breath at moderate physical exercise, lower extremity edema that appeared in the afternoon and disappeared by the morning.In addition, 33 (32,4%) surveyed patients indicated a periodic heartbeat.In 18 (17,7%) patients sporadic dizziness was observed. The level of blood pressure (BP), which was established in the studied patients, corresponded to arterial hypertension of grade 1-2 (154,15 ± 9,24 / 94,53 ± 9,05 mm Hg). In terms of heart rate (HR) in the examined patients, it was 80.26 ± 10.73 beats per minute. CONCLUSION: Conclusions: According to the study, the negative impact of concomitant hypertension on the clinical course of chronic pancreatitis was established, namely: hypertension in most cases causes intensification of pain syndrome; pain syndrome in comorbid patients with cronic pancreatitis and arterial hypertension is accompanied by more pronounced manifestations of asthenisation: general weakness, lethargy;dependence of the duration of pain syndrome from the height of blood pressure and the duration of arterial hypertension was found; dyspepsia syndrome is more pronounced, varied and prolonged in patients with high blood pressure; smoking (37,3%), alcohol (19,6%), psychoemotional overload (6,9%) are common etiologic factors in comorbid patients with chronic pancreatitis and arterial hypertension; BMI results indicate the dominance of excess body mass in most comorbid patients with chronic pancreatitis and arterial hypertension.