Detalhe da pesquisa
1.
Development of a highly potent and selective degrader of LRRK2.
Bioorg Med Chem Lett
; 94: 129449, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37591317
2.
Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding.
Biochem J
; 479(17): 1759-1783, 2022 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35950872
3.
Stress and mental health of COVID-19 survivors and their families after hospital discharge: relationship with perceived healthcare staff empathy.
Psychol Health Med
; 28(1): 48-59, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34931918
4.
Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.
EMBO J
; 37(1): 1-18, 2018 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29212815
5.
A chemical-genetics approach to study the role of atypical Protein Kinase C in Drosophila.
Development
; 146(2)2019 01 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-30635282
6.
Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's Disease.
Mol Cell Proteomics
; 19(9): 1546-1560, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32601174
7.
Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites.
Biochem J
; 478(2): 299-326, 2021 01 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33367571
8.
Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.
Biochem J
; 478(3): 553-578, 2021 02 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33459343
9.
Clinical-radiological correlations in COVID-19-related venous thromboembolism: Preliminary results from a multidisciplinary study.
Int J Clin Pract
; 75(9): e14370, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-33998752
10.
The chaperone activity of 4PBA ameliorates the skeletal phenotype of Chihuahua, a zebrafish model for dominant osteogenesis imperfecta.
Hum Mol Genet
; 26(15): 2897-2911, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28475764
11.
Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase.
Biochem J
; 475(1): 1-22, 2018 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29127256
12.
The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.
Biochem J
; 475(11): 1861-1883, 2018 06 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29743203
13.
Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.
EMBO J
; 38(2)2019 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30647193
14.
Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors.
Biochem J
; 473(17): 2671-85, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27474410
15.
TGFß1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation.
FASEB J
; 27(11): 4532-46, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23913862
16.
Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson's disease.
bioRxiv
; 2024 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38293195
17.
Low-molecular-weight heparin for the prevention of clinical worsening in severe non-critically ill COVID-19 patients: a joint analysis of two randomized controlled trials.
Intern Emerg Med
; 19(1): 71-79, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37794281
18.
RAB32 Ser71Arg in autosomal dominant Parkinson's disease: linkage, association, and functional analyses.
Lancet Neurol
; 23(6): 603-614, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38614108
19.
A pathogenic variant in RAB32 causes autosomal dominant Parkinson's disease and activates LRRK2 kinase.
medRxiv
; 2024 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38293014
20.
Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2.
Science
; 382(6677): 1404-1411, 2023 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38127736