Observation of Linear and Nonlinear Light Localization at the Edges of Moiré Arrays.

We observe linear and nonlinear light localization at the edges and in the corners of truncated moiré arrays created by the superposition of periodic mutually twisted at Pythagorean angles square sublattices. Experimentally exciting corner linear modes in the femtosecond-laser written moiré arrays we find drastic differences in their localization properties in comparison with the bulk excitations. We also address the impact of nonlinearity on the corner and bulk modes and experimentally observe the crossover from linear quasilocalized states to the surface solitons emerging at the higher input powers. Our results constitute the first experimental demonstration of localization phenomena induced by truncation of periodic moiré structures in photonic systems.

Observation of Edge Solitons in Topological Trimer Arrays.

We report the experimental observation of nonlinear light localization and edge soliton formation at the edges of fs-laser written trimer waveguide arrays, where transition from nontopological to topological phases is controlled by the spacing between neighboring trimers. We found that, in the former regime, edge solitons occur only above a considerable power threshold, whereas in the latter one they bifurcate from linear states. Edge solitons are observed in a broad power range where their propagation constant falls into one of the topological gaps of the system, while partial delocalization is observed when considerable nonlinearity drives the propagation constant into an allowed band, causing coupling with bulk modes. Our results provide direct experimental evidence of the coexistence and selective excitation in the same or in different topological gaps of two types of topological edge solitons with different internal structures, which can rarely be observed even in nontopological systems. This also constitutes the first experimental evidence of formation of topological solitons in a nonlinear system with more than one topological gap.

Metabolic and neurological consequences of the treatment with polyphenols: a systematic review in rodent models of noncommunicable diseases.

BACKGROUND: Noncommunicable diseases (NCDs) lead to drastic metabolic alterations with associated energy balance and body weight changes, two related physiological processes regulated by the brain. Polyphenol-based treatments for NCDs have emerged as a promising therapy, which seems to involve the energy balance modulation. However, it remains unclear what the most effective polyphenols-based treatment is to attenuate adverse effects in the energy balance of NCDs. OBJECTIVES: This systematic review aimed to evaluate the literature on the metabolic and neurological effects of polyphenols-based treatment in rodent models of NCDs. METHODS: Literature search was carried out in the following databases: CINAHL, Medline/PubMed, SCOPUS, and Web of Science. For title and abstract screening, original papers with polyphenols exposure in rodents were selected. For full-text screening, studies with models of NCDs that reported metabolic and neurological outcomes when treated with polyphenols were selected for inclusion in this review. RESULTS: 23 articles, using individual compound (11 articles) or polyphenols extracts (12 articles), were included in this review: 5 articles using tea polyphenols, 12 articles using grape-derived polyphenols, 3 articles using the polyphenol quercetin, and 3 articles using other polyphenol sources. Most results agree on the beneficial effect of polyphenols in attenuating alterations in energy balance and body weight. Such effects were associated with neuroprotective responses in different brain areas including hippocampus and hypothalamus. CONCLUSION: In conclusion, this review shows that the treatment with polyphenols, especially resveratrol or quercetin, attenuates the adverse effects of NCDs on energy balance and are associated with neuroprotective effects.

Nonlinear higher-order polariton topological insulator.

We address the resonant response and bistability of the exciton-polariton corner states in a higher-order nonlinear topological insulator realized with a kagome arrangement of microcavity pillars. Such states are resonantly excited and exist due to the balance between pump and losses, on one hand, and between nonlinearity and dispersion in inhomogeneous potential landscape, on the other hand, for pump energy around eigen-energies of corresponding linear localized modes. Localization of the nonlinear corner states in a higher-order topological insulator can be efficiently controlled by tuning pump energy. We link the mechanism of corner state formation with symmetry of the truncated kagome array. Corner states coexist with densely packed edge states but are well isolated from them in energy. Nonlinear corner states persist even in the presence of perturbations in a corner microcavity pillar.

Nasal Model Experiments Show That a Collimated Fluid Delivers Precise Doses to the Human Olfactory Cavity in the Side-Laying Position.

The nasal administration of therapeutic fluids and vaccines is used to treat allergic rhinitis, sinusitis, congestion, coronaviruses and even Alzheimer's disease. In the latter, the drug must reach the olfactory region, so it finds its way into the central nervous system. Effective administration techniques able to reach the olfactory region are challenging due to the tortuous anatomy of the nasal cavity, and are frequently evaluated in vitro using transparent anatomical models. Here, the liquid distribution inside a 3D printed human nasal cavity is quantified for model fluids resulting from the discharge of a 1-mL syringe with either a spray-generating nozzle, and a straight tip emitting a collimated fluid stream. Experiments using two model fluids with different viscosities suggest that a simple, correctly positioned straight tip attached to a syringe is able to efficiently deliver most of a therapeutic fluid in the human olfactory region in the side-laying position, avoiding the adoption of head-back and head-down positions that can be difficult for patients in the age range typical of Alzheimer's disease. Furthermore, we demonstrate by computer simulations that the conclusion is valid within a wide range of parameters.

Observation of the gradual transition from one-dimensional to two-dimensional Anderson localization.

We study the gradual transition from one-dimensional (1D) to two-dimensional (2D) Anderson localization upon transformation of the dimensionality of disordered waveguide arrays. An effective transition from a 1D to a 2D system is achieved by increasing the number of rows forming the arrays. We observe that, for a given disorder level, Anderson localization becomes weaker with increasing numbers of rows-hence the effective dimension.

Anderson cross-localization.

We report Anderson localization in two-dimensional optical waveguide arrays with disorder in waveguide separation introduced along one axis of the array, in an uncorrelated fashion for each waveguide row. We show that the anisotropic nature of such disorder induces a strong localization along both array axes. The degree of localization in the cross-axis remains weaker than that in the direction in which disorder is introduced. This effect is illustrated both theoretically and experimentally.

Vortex twins and anti-twins supported by multiring gain landscapes.

We address the properties of multivortex soliton complexes supported by multiring gain landscapes in focusing Kerr nonlinear media with strong two-photon absorption. Stable complexes incorporating two, three, or four vortices featuring opposite or identical topological charges are shown to exist. In the simplest geometries with two amplifying rings vortex twins with equal topological charges exhibit asymmetric intensity distributions, while vortex anti-twins may be symmetric or asymmetric, depending on the gain level and separation between rings.

Wave localization at the boundary of disordered photonic lattices.

We report on the experimental observation of reduced light-energy transport and disorder-induced localization close to a boundary of a truncated 1D disordered photonic lattice. Our observations uncover that a higher level of disorder near the boundary is required to obtain similar localization than in the bulk.

Three-dimensional light bullets in arrays of waveguides.

We report the first experimental observation of three-dimensional light bullets, excited by femtosecond pulses in a system featuring quasi-instantaneous cubic nonlinearity and a periodic, transversally modulated refractive index. Stringent evidence of the excitation of light bullets is based on time-gated images and spectra which perfectly match our numerical simulations. Furthermore, we reveal a novel evolution mechanism forcing the light bullets to follow varying dispersion or diffraction conditions, until they leave their existence range and decay.

Light tunneling inhibition and anisotropic diffraction engineering in two-dimensional waveguide arrays.

We address two-dimensional (2D) waveguide arrays where light tunneling into neighboring waveguides may be effectively suppressed by an out-of-phase harmonic modulation of the refractive index in neighboring waveguides at suitable frequencies. Genuine 2D features, such as anisotropic diffraction engineering, diffraction-free propagation along selected directions in the transverse plane, and tunneling inhibition for multichannel vortices, are shown to occur.

Observation of two-dimensional superlattice solitons.

We observe experimentally two-dimensional solitons in superlattices comprising alternating deep and shallow waveguides fabricated via the femtosecond-laser direct writing technique. We find that the symmetry of linear diffraction patterns as well as soliton shapes and threshold powers largely differ for excitations centered on deep and shallow sites. Thus, bulk and surface solitons centered on deep waveguides require much lower powers than their counterparts on shallow sites.

Nonlinearity-induced broadening of resonances in dynamically modulated couplers.

We report the observation of nonlinearity-induced broadening of resonances in dynamically modulated directional couplers. When the refractive index of the guiding channels in the coupler is harmonically modulated along the propagation direction and is out-of-phase in two channels, coupling can be completely inhibited at resonant modulation frequencies. We observe that nonlinearity broadens such resonances and that localization can be achieved even in detuned systems at power levels well below those required in unmodulated couplers.

Stable three-dimensional optical solitons supported by competing quadratic and self-focusing cubic nonlinearities.

We show that the quadratic (chi(2)) interaction of fundamental and second harmonics in a bulk dispersive medium, combined with self-focusing cubic (chi(3)) nonlinearity, give rise to stable three-dimensional spatiotemporal solitons (STSs), despite the possibility of the supercritical collapse, induced by the chi(3) nonlinearity. At exact phase matching (beta = 0) , the STSs are stable for energies from zero up to a certain maximum value, while for beta not equal 0 the solitons are stable in energy intervals between finite limits.

Three-dimensional spatiotemporal optical solitons in nonlocal nonlinear media.

We demonstrate the existence of stable three-dimensional spatiotemporal solitons (STSs) in media with a nonlocal cubic nonlinearity. Fundamental (nonspinning) STSs forming one-parameter families are stable if their propagation constant exceeds a certain critical value that is inversely proportional to the range of nonlocality of nonlinear response. All spinning three-dimensional STSs are found to be unstable.

Stable solitons of even and odd parities supported by competing nonlocal nonlinearities.

We introduce a one-dimensional phenomenological model of a nonlocal medium featuring focusing cubic and defocusing quintic nonlocal optical nonlinearities. By means of numerical methods, we find families of solitons of two types, even-parity (fundamental) and dipole-mode (odd-parity) ones. Stability of the solitons is explored by means of computation of eigenvalues associated with modes of small perturbations, and tested in direct simulations. We find that the stability of the fundamental solitons strictly follows the Vakhitov-Kolokolov criterion, whereas the dipole solitons can be destabilized through a Hamiltonian-Hopf bifurcation. The solitons of both types may be stable in the nonlocal model with only quintic self-attractive nonlinearity, in contrast with the instability of all solitons in the local version of the quintic model.

Anxiolytic and anti-stress effects of brain prolactin: improved efficacy of antisense targeting of the prolactin receptor by molecular modeling.

We provide the first evidence that prolactin is a neuromodulator of behavioral and neuroendocrine stress coping in the rat. In virgin female and male rats, intracerebral infusion of ovine prolactin (oPRL) into the lateral cerebral ventricle (intracerebroventricular) exerted an anxiolytic effect on the elevated plus-maze in a dose-dependent manner (0.1 and 1.0 microg/5 microl; p < 0.01). In contrast, downregulation of the expression of the long form of brain prolactin receptors by chronic intracerebroventricular infusion of an antisense oligodeoxynucleotide (ODN) (osmotic minipump, 0.5 microg. 0.5 microl(-1). hr(-1); 5 d) increased anxiety-related behavior on the plus-maze compared with mixed bases-treated and vehicle-treated rats (p < 0.01), again demonstrating an anxiolytic effect of PRL acting at brain level. Furthermore, in jugular vein-catheterized female rats, the stress-induced increase of corticotropin secretion was decreased after chronic intracerebroventricular infusion of oPRL (osmotic minipump, 1.0 microg. 0.5 microl(-1). hr(-1); p < 0.05) and, in contrast, was further elevated by antisense targeting of the brain prolactin receptors (p < 0.01). This provides evidence for a receptor-mediated attenuation of the responsiveness of the hypothalamo-pituitary-adrenal (HPA) axis by prolactin. The antisense ODN sequence was selected on the basis of secondary structure molecular modeling of the target mRNA to improve antisense ODN-mRNA hybridization. Receptor autoradiography confirmed the expected improvement in the efficacy of downregulation of prolactin receptor expression [empirically designed antisense, 30%; p > 0.05, not significant; adjustment of target position after mRNA modeling, 72%; p < 0.05). Taken together, prolactin acting at brain level has to be considered as a novel regulator of both emotionality and HPA axis reactivity.

No stress response of the hypothalamo-pituitary-adrenal axis in parturient rats: lack of involvement of brain oxytocin.

During parturition, the basal activity of the hypothalamo-pituitary-adrenal (HPA) axis of Wistar rats is strongly attenuated, whereas the oxytocin system is activated. We investigated the secretory responses of the HPA axis and oxytocin to exposure to a mild emotional stressor (airpuff) comparing virgin female, d 22 pregnant, and parturient rats. Furthermore, as the brain oxytocin system is activated in parturition and oxytocin has been shown to inhibit HPA axis responses in virgin rats, the role of brain oxytocin in the regulation of stress responses during parturition was investigated by intracerebroventricular administration of an oxytocin receptor antagonist before stressor exposure (0.75 micro g/5 micro l). In virgin female rats, exposure to airpuff increased ACTH (2.5 +/- 0.34-fold) and corticosterone (5.1 +/- 2.3-fold) secretion, but in late pregnancy and parturition, the stress-induced increase in ACTH (pregnancy: 1.9 +/- 0.41-fold; parturition: 1.3 +/- 0.13-fold) and corticosterone secretion (parturition: 1.8 +/- 0.40-fold) were strongly attenuated. Oxytocin secretion remained unchanged in response to airpuff in both virgin and parturient rats despite higher overall plasma concentrations in the latter. Oxytocin receptor blockade in the brain elevated basal and stress-induced ACTH secretion in virgin but not pregnant or parturient rats and had no effect on oxytocin secretion either in virgin or parturient rats. We conclude that the reactivity of the HPA axis to external stressors is strongly attenuated during parturition, and this cannot be disinhibited by blocking the receptor-mediated action of brain oxytocin.

A 14-kilodalton prolactin-like fragment is secreted by the hypothalamo-neurohypophyseal system of the rat.

The recently described expression of the PRL gene, and the occurrence of a 14-kilodalton (kDa)PRL-like immunoreactive protein in the hypothalamo-neurohypophyseal system of the rat have raised the possibility that PRL variants are released from neurohypophyseal terminals into the blood. In this study, we investigated the local production of a hypothalamo-neurohypophyseal 14-kDa PRL-like protein by showing an independent origin from adenohypophyseal PRL. No 14-kDa PRL-like protein was detected in adenohypophyseal extracts by Western blots, whereas chronic hypophysectomy produced no change in the immunocytochemical detection of PRLs in supraoptic and paraventricular magnocellular neurons. In addition, a 14-kDa immunoreactive PRL-like protein was released into the medium by incubated neurohypophyseal lobes. Western blot analysis showed that significantly more of this 14-kDa protein was released into calcium-containing medium (1.8 mM) than into calcium-free medium. Furthermore, depolarizing concentrations of potassium (56 mM) increased by 3-fold the release of immunoreactive PRL by incubated hypothalamo-neurohypophyseal explants. In addition, a 14-kDa PRL-like antigen was detected in the circulation of the rat by Western blot analysis. These results are consistent with the local synthesis and calcium-dependent release of neurohypophyseal PRL-like proteins that include a predominant 14-kDa form.

Brain oxytocin: differential inhibition of neuroendocrine stress responses and anxiety-related behaviour in virgin, pregnant and lactating rats.

The involvement of brain oxytocin in the attenuated responsiveness of the hypothalamo-pituitary-adrenal axis and the oxytocin systems to external stressors found in pregnant and lactating rats has been studied, including both neuroendocrine and behavioural aspects. Intracerebroventricular infusion of an oxytocin receptor antagonist (0.75 microg/5 microl), but not of vehicle, elevated basal corticotropin and corticosterone secretion into blood of virgin female, but not of late pregnant or lactating rats. Oxytocin antagonist treatment further elevated the stress-induced (exposure to the elevated plus-maze or forced swimming) secretion of both corticotropin and corticosterone, but only in virgin and not in pregnant or lactating rats. Thus, corticotropin and corticosterone plasma concentrations remained attenuated in antagonist-treated pregnant and lactating animals. In contrast, infusion of the oxytocin antagonist significantly elevated the stress-induced secretion of oxytocin into blood in pregnant and lactating, but not in virgin, animals, indicating an autoinhibitory influence of intracerebral oxytocin on neurohypophysial oxytocin secretion induced by non-reproduction-related stimuli. Treatment with oxytocin antagonist 10 min prior to behavioural testing on the elevated plus-maze significantly reduced the anxiety-related behaviour in both pregnant and lactating rats, without exerting similar effects in virgin female rats. The results demonstrate a tonic inhibitory effect of endogenous oxytocin on corticotropin and, consequently, corticosterone secretion in virgin female rats, an effect which is absent in the peripartum period. In contrast, an anxiolytic action of endogenous oxytocin was detectable exclusively in pregnant and lactating rats. Therefore, we conclude that the actions of intracerebral oxytocin include independent effects on the responses of the hypothalamo-pituitary-adrenal axis and oxytocin systems to stressors and the anxiety-related behaviour which are modulated by the reproductive state of the animals.