Trichodysplasia spinulosa in a child: Identification of trichodysplasia spinulosa-associated polyomavirus in skin, serum, and urine.

A 6-year-old girl with a history of chronic immunosuppression following small bowel and colon transplantation for tufting enteropathy presented with a diffuse, facial-predominant eruption composed of pink-to-skin-colored papules with central white dystrophic spicules. Histology from a punch biopsy and polymerase chain reaction (PCR) from plucked spicules confirmed a diagnosis of trichodysplasia spinulosa (TS). Additional molecular studies identified several strains of the trichodysplasia spinulosa-associated polyomavirus infecting multiple tissues of the patient, confirming the systemic nature of trichodysplasia spinulosa infections.

Complications in body contouring stratified according to weight loss method.

BACKGROUND: Body contouring procedures following massive weight loss have become increasingly common and, unfortunately, continue to be associated with a high complication rate. OBJECTIVE: To evaluate how weight loss method affects complications following abdominally based body contouring procedures. METHODS: Patients undergoing abdominally based contouring procedures were retrospectively evaluated over an 11-year period and stratified into two groups based on method of weight loss: diet and exercise; or bariatric surgery. Complications, including seroma, wound dehiscence, skin necrosis, infection, hematoma and venous thromboembolism, were included if they required intervention. An adjusted logistic model was used to examine the effect of weight loss method on aggregate complication rates. RESULTS: A total of 307 patients were included: 77 (25%) lost weight through diet and exercise; and 230 (75%) through bariatric surgery. Results from the logistic model showed no difference in complication rates between weight loss methods (OR 1.01 [95% CI 0.51 to 2.02]). However, there was a strong correlation between body mass index at the time of surgery and complication rates (OR 1.05 [95% CI 1.02 to 1.08]; P<0.01). CONCLUSIONS: The findings reveal no difference in complication rates following abdominal body contouring procedures attributable to method of weight loss. Rather, there was a proportional rise in complication rates in patients with a higher body mass index at the time of surgery. Surgeons and patients should be aware of this trend, and it should be part of any discussion of abdominal body contouring procedures and informing patients of their risk profile.

HISTORIQUE: Les interventions de remodelage du corps après une perte de poids massive sont de plus en plus courantes. Malheureusement, elles continuent d'être associées à un taux de complication élevé. OBJECTIF: Évaluer l'influence de la méthode de perte de poids sur les complications après des interventions de remodelage de l'abdomen. MÉTHODOLOGIE: Les chercheurs ont fait l'évaluation rétrospective de patients qui avaient subi des interventions de remodelage sur une période de 11 ans et les ont stratifiés en deux groupes, selon la méthode de perte de poids: régime et exercice ou chirurgie bariatrique. Ils ont inclus les complications qui avaient nécessité une intervention, y compris le sérome, la déhiscence de la plaie, la nécrose cutanée, l'infection, l'hématome et la thromboembolie veineuse. Ils ont utilisé un modèle logistique rajusté pour examiner l'effet de la méthode de perte de poids sur les taux de complication globaux. RÉSULTATS: Au total, 307 patients ont été inclus dans l'étude, dont 77 (25 %) ont perdu du poids par suite d'un régime et d'exercice et 230 (75 %) après une chirurgie bariatrique. Les résultats du modèle logistique n'ont révélé aucune différence dans les taux de complications selon la méthode de perte de poids (RC 1,01 [95 % IC 0,51 à 2,02]). Cependant, ils ont constaté une forte corrélation entre l'indice de masse corporelle au moment de l'opération et les taux de complications (RC 1,05 [95 % IC 1,02 à 1,08]; P<0,01). CONCLUSIONS: Les résultats n'ont révélé aucune différence dans les taux de complication attribuables à la méthode de perte de poids après des interventions de remodelage abdominal. Ils ont plutôt démontré une augmentation proportionnelle des taux de complication chez les patients dont l'indice de masse corporelle était plus élevé lors de l'opération. Les chirurgiens et les patients devraient connaître cette tendance, qu'il faudrait intégrer aux discussions sur les interventions de remodelage abdominal et à l'information aux patients sur leur profil de risque.

Dermal damage promoted by repeated low-level UV-A1 exposure despite tanning response in human skin.

IMPORTANCE: Solar UV irradiation causes photoaging, characterized by fragmentation and reduced production of type I collagen fibrils that provide strength to skin. Exposure to UV-B irradiation (280-320 nm) causes these changes by inducing matrix metalloproteinase 1 and suppressing type I collagen synthesis. The role of UV-A irradiation (320-400 nm) in promoting similar molecular alterations is less clear yet important to consider because it is 10 to 100 times more abundant in natural sunlight than UV-B irradiation and penetrates deeper into the dermis than UV-B irradiation. Most (approximately 75%) of solar UV-A irradiation is composed of UV-A1 irradiation (340-400 nm), which is also the primary component of tanning beds. OBJECTIVE: To evaluate the effects of low levels of UV-A1 irradiation, as might be encountered in daily life, on expression of matrix metalloproteinase 1 and type I procollagen (the precursor of type I collagen). DESIGN, SETTING, AND PARTICIPANTS: In vivo biochemical analyses were conducted after UV-A1 irradiation of normal human skin at an academic referral center. Participants included 22 healthy individuals without skin disease. MAIN OUTCOMES AND MEASURES: Skin pigmentation was measured by a color meter (chromometer) under the L* variable (luminescence), which ranges from 0 (black) to 100 (white). Gene expression in skin samples was assessed by real-time polymerase chain reaction. RESULTS: Lightly pigmented human skin (L* >65) was exposed up to 4 times (1 exposure/d) to UV-A1 irradiation at a low dose (20 J/cm2), mimicking UV-A levels from strong sun exposure lasting approximately 2 hours. A single exposure to low-dose UV-A1 irradiation darkened skin slightly and did not alter matrix metalloproteinase 1 or type I procollagen gene expression. With repeated low-dose UV-A1 irradiation, skin darkened incrementally with each exposure. Despite this darkening, 2 or more exposures to low-dose UV-A1 irradiation significantly induced matrix metalloproteinase 1 gene expression, which increased progressively with successive exposures. Repeated UV-A1 exposures did not suppress type I procollagen expression. CONCLUSIONS AND RELEVANCE: A limited number of low-dose UV-A1 exposures, as commonly experienced in daily life, potentially promotes photoaging by affecting breakdown, rather than synthesis, of collagen. Progressive skin darkening in response to repeated low-dose UV-A1 exposures in lightly pigmented individuals does not prevent UV-A1-induced collagenolytic changes. Therefore, for optimal protection against skin damage, sunscreen formulations should filter all UV wavelengths, including UV-A1 irradiation.