Detalhe da pesquisa
1.
Structural and functional insights into the inhibition of human voltage-gated sodium channels by µ-conotoxin KIIIA disulfide isomers.
J Biol Chem
; 298(3): 101728, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35167877
2.
Changes in Potency and Subtype Selectivity of Bivalent NaV Toxins are Knot-Specific.
Bioconjug Chem
; 34(6): 1072-1083, 2023 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37262436
3.
Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7.
J Biol Chem
; 295(15): 5067-5080, 2020 04 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32139508
4.
Evaluation of Efficient Non-reducing Enzymatic and Chemical Ligation Strategies for Complex Disulfide-Rich Peptides.
Bioconjug Chem
; 32(11): 2407-2419, 2021 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34751572
5.
Enzymatic Ligation of a Pore Blocker Toxin and a Gating Modifier Toxin: Creating Double-Knotted Peptides with Improved Sodium Channel NaV1.7 Inhibition.
Bioconjug Chem
; 31(1): 64-73, 2020 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31790574
6.
Evaluation of Peptide Ligation Strategies for the Synthesis of the Bivalent Acid-Sensing Ion Channel Inhibitor Hi1a.
Org Lett
; 25(24): 4439-4444, 2023 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37306339
7.
Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function.
Nat Commun
; 14(1): 2442, 2023 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37117223
8.
On the Utility of Chemical Strategies to Improve Peptide Gut Stability.
J Med Chem
; 65(8): 6191-6206, 2022 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35420805
9.
µ-Conotoxins Targeting the Human Voltage-Gated Sodium Channel Subtype NaV1.7.
Toxins (Basel)
; 14(9)2022 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36136538
10.
The Allosteric Activation of α7 nAChR by α-Conotoxin MrIC Is Modified by Mutations at the Vestibular Site.
Toxins (Basel)
; 13(8)2021 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34437426
11.
Improving the Gastrointestinal Stability of Linaclotide.
J Med Chem
; 64(12): 8384-8390, 2021 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33979161
12.
Chemical Synthesis of TFF3 Reveals Novel Mechanistic Insights and a Gut-Stable Metabolite.
J Med Chem
; 64(13): 9484-9495, 2021 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34142550
13.
Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible NaV Channel Inhibitor.
Biomedicines
; 8(10)2020 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33023152