1.
Hum Genet
; 124(3): 304, 2008 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18846634
2.
J Neuroimmunol
; 210(1-2): 100-3, 2009 May 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19359048
RESUMO
Caspase-9 is a primary effector CASP that executes programmed cell death, which plays an important role in the development of multiple sclerosis (MS). Polymorphisms in the CASP-9 gene may influence its activity, thereby modulating the susceptibility to MS. To test this hypothesis, we evaluated a SNP in the CASP-9 gene in a set of Italian patients from Southern Italy and healthy control subjects. Our results suggest that the presence of the G/G genotype represents a higher risk factor in our MS population and a differential production of CASP-9 might be a contributory factor in determining the severity of MS.