Detalhe da pesquisa
1.
Structure-Guided Discovery of PD-1/PD-L1 Interaction Inhibitors: Peptide Design, Screening, and Optimization via Computation-Aided Phage Display Engineering.
J Chem Inf Model
; 64(5): 1615-1627, 2024 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38356220
2.
Pharmacological and mechanistic study of PS1, a Pdia4 inhibitor, in ß-cell pathogenesis and diabetes in db/db mice.
Cell Mol Life Sci
; 80(4): 101, 2023 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36935456
3.
Single-chain fragment antibody disrupting the EphA4 function as a therapeutic drug for gastric cancer.
Biochem Biophys Res Commun
; 680: 161-170, 2023 11 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37741263
4.
An auristatin-based antibody-drug conjugate targeting EphA2 in pancreatic cancer treatment.
Biochem Biophys Res Commun
; 688: 149214, 2023 12 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37951154
5.
Isolation of Anti-SARS-CoV-2 Natural Products Extracted from Mentha canadensis and the Semi-synthesis of Antiviral Derivatives.
J Nat Prod
; 86(6): 1428-1436, 2023 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37267066
6.
Design, structure-activity relationships, and enzyme kinetic studies of tricyclic and tetracyclic coumarin-based sulfamates as steroid sulfatase inhibitors.
Bioorg Chem
; 138: 106581, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37172437
7.
The Blockade of Mitogen-Activated Protein Kinase 14 Activation by Marine Natural Product Crassolide Triggers ICD in Tumor Cells and Stimulates Anti-Tumor Immunity.
Mar Drugs
; 21(4)2023 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37103364
8.
Targeting spike protein-induced TLR/NET axis by COVID-19 therapeutic NRICM102 ameliorates pulmonary embolism and fibrosis.
Pharmacol Res
; 184: 106424, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36064077
9.
Curbing COVID-19 progression and mortality with traditional Chinese medicine among hospitalized patients with COVID-19: A propensity score-matched analysis.
Pharmacol Res
; 184: 106412, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36007774
10.
The Design, Structure-Activity, and kinetic studies of 3-Benzyl-5-oxa-1,2,3,4-Tetrahydro-2H-chromeno-(3,4-c)pyridin-8-yl sulfamates as Steroid sulfatase inhibitors.
Bioorg Chem
; 129: 106148, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36244324
11.
Design and synthesis of 3-benzylaminocoumarin-7-O-sulfamate derivatives as steroid sulfatase inhibitors.
Bioorg Chem
; 96: 103618, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32059152
12.
Generation and characterization of avian-derived anti-human CD19 single chain fragment antibodies.
Anim Biotechnol
; 30(4): 293-301, 2019 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-30261812
13.
Corrigendum to "Single-chain fragment antibody disrupting the EphA4 function as a therapeutic drug for gastric cancer" [Biochem. Biophys. Res. Commun. 680 (2023) 161-170].
Biochem Biophys Res Commun
; 686: 149085, 2023 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37839952
14.
GSK-3 inhibition through GLP-1R allosteric activation mediates the neurogenesis promoting effect of P7C3 after cerebral ischemic/reperfusional injury in mice.
Toxicol Appl Pharmacol
; 357: 88-105, 2018 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30189238
15.
New Hirsutinolide-Type Sesquiterpenoids from Vernonia cinerea Inhibit Nitric Oxide Production in LPS-Stimulated RAW264.7 Cells.
Planta Med
; 84(18): 1348-1354, 2018 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-29986352
16.
Peramivir analogues bearing hydrophilic side chains exhibit higher activities against H275Y mutant than wild-type influenza virus.
Org Biomol Chem
; 15(46): 9910-9922, 2017 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-29159346
17.
Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO.
J Biomed Sci
; 23: 27, 2016 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26892079
18.
Comparative study between 3D-QSAR and Docking-Based Pharmacophore models for potent Plasomodium falciparum dihydroorotate dehydrogenase inhibitors.
Bioorg Med Chem Lett
; 26(2): 265-271, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26707392
19.
Phage display-mediated discovery of novel tyrosinase-targeting tetrapeptide inhibitors reveals the significance of N-terminal preference of cysteine residues and their functional sulfur atom.
Mol Pharmacol
; 87(2): 218-30, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25403678
20.
Single chain antibody fragment with serine protease inhibitory property capable of neutralizing toxicity of Trimeresurus mucrosquamatus venom.
Biochem Biophys Res Commun
; 460(2): 170-6, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25769957