Detalhe da pesquisa
1.
Effects of lasmiditan on simulated driving performance: Results of two randomized, blinded, crossover studies with placebo and active controls.
Hum Psychopharmacol
; 35(5): e2732, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32449213
2.
The pharmacokinetics and pharmacodynamics of alogliptin in children, adolescents, and adults with type 2 diabetes mellitus.
Eur J Clin Pharmacol
; 73(3): 279-288, 2017 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-27999883
3.
A human [(11)C]T-773 PET study of PDE10A binding after oral administration of TAK-063, a PDE10A inhibitor.
Neuroimage
; 141: 10-17, 2016 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27423256
4.
Single-dose pharmacokinetics and safety of azilsartan medoxomil in children and adolescents with hypertension as compared to healthy adults.
Eur J Clin Pharmacol
; 72(4): 447-57, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26725367
5.
Investigation of the Effect of Lasmiditan on the Pharmacokinetics of P-Glycoprotein and Breast Cancer Resistance Protein Substrates.
J Clin Pharmacol
; 64(1): 94-102, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37566903
6.
Population pharmacokinetics, enzyme occupancy, and 24S-hydroxycholesterol modeling of soticlestat, a novel cholesterol 24-hydroxylase inhibitor, in healthy adults.
Clin Transl Sci
; 16(7): 1149-1162, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37212649
7.
The effects of xanthine oxidase inhibition by febuxostat on the pharmacokinetics of theophylline.
Int J Clin Pharmacol Ther
; 50(5): 331-7, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22541837
8.
Safety, Tolerability, and Pharmacokinetics of Mevidalen (LY3154207), a Centrally Acting Dopamine D1 Receptor-Positive Allosteric Modulator, in Patients With Parkinson Disease.
Clin Pharmacol Drug Dev
; 11(3): 324-332, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34664427
9.
Safety, Tolerability, and Pharmacokinetics of Mevidalen (LY3154207), a Centrally Acting Dopamine D1 Receptor-Positive Allosteric Modulator (D1PAM), in Healthy Subjects.
Clin Pharmacol Drug Dev
; 10(4): 393-403, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33029934
10.
Pharmacokinetics, Safety, and Tolerability of Lasmiditan in Pediatric Patients with Migraine.
Clin Pharmacokinet
; 60(6): 819-828, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33565026
11.
An experimental medicine study of the phosphodiesterase-4 inhibitor, roflumilast, on working memory-related brain activity and episodic memory in schizophrenia patients.
Psychopharmacology (Berl)
; 238(5): 1279-1289, 2021 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-30536081
12.
The effects of roflumilast, a phosphodiesterase type-4 inhibitor, on EEG biomarkers in schizophrenia: A randomised controlled trial.
J Psychopharmacol
; 35(1): 15-22, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32854568
13.
Effects of Lasmiditan on Cardiovascular Parameters and Pharmacokinetics in Healthy Subjects Receiving Oral Doses of Propranolol.
Clin Pharmacol Drug Dev
; 9(5): 629-638, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31950732
14.
Abuse Potential of Lasmiditan: A Phase 1 Randomized, Placebo- and Alprazolam-Controlled Crossover Study.
J Clin Pharmacol
; 60(4): 495-504, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31745991
15.
Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study.
Neurobiol Aging
; 77: 37-43, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30776650
16.
Tumor-penetrating microparticles for intraperitoneal therapy of ovarian cancer.
J Pharmacol Exp Ther
; 327(3): 673-82, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18780831
17.
A Nonhuman Primate PET Study: Measurement of Brain PDE4 Occupancy by Roflumilast Using (R)-[11C]Rolipram.
Mol Imaging Biol
; 20(4): 615-622, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29441434
18.
A Randomized Multiple Dose Pharmacokinetic Study of a Novel PDE10A Inhibitor TAK-063 in Subjects with Stable Schizophrenia and Japanese Subjects and Modeling of Exposure Relationships to Adverse Events.
Drugs R D
; 17(4): 631-643, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-29103081
19.
Population Pharmacokinetics and Exposure-Response of a Fixed-Dose Combination of Azilsartan Medoxomil and Chlorthalidone in Patients With Stage 2 Hypertension.
J Clin Pharmacol
; 56(8): 988-98, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26632101
20.
A phase 1 study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of TAK-063, a selective PDE10A inhibitor.
Psychopharmacology (Berl)
; 233(21-22): 3787-3795, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27572830