Detalhe da pesquisa
1.
Metabolic activation and major protein target of a 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonist.
Chem Res Toxicol
; 25(7): 1412-22, 2012 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22765480
2.
Minimizing metabolic activation during pharmaceutical lead optimization: progress, knowledge gaps and future directions.
Curr Opin Drug Discov Devel
; 11(1): 43-52, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18175266
3.
Comparative disposition and metabolism of paraherquamide in sheep, gerbils, and dogs.
Drug Metab Dispos
; 36(8): 1659-69, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18505789
4.
Molecular modeling-guided site-directed mutagenesis of cytochrome P450 2D6.
Curr Drug Metab
; 8(1): 59-77, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17266524
5.
Topological role of cytochrome P450 2D6 active site residues.
Arch Biochem Biophys
; 447(1): 53-8, 2006 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16466686
6.
Species differences in metabolism and pharmacokinetics of a sphingosine-1-phosphate receptor agonist in rats and dogs: formation of a unique glutathione adduct in the rat.
Drug Metab Dispos
; 34(8): 1367-75, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16698892
7.
Substituent effect on the reductive N-dearylation of 3-(indol-1-yl)-1,2-benzisoxazoles by rat liver microsomes.
Drug Metab Dispos
; 31(8): 999-1004, 2003 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12867488
8.
Vanadium haloperoxidase-catalyzed bromination and cyclization of terpenes.
J Am Chem Soc
; 125(13): 3688-9, 2003 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-12656585
9.
Tryptophan-14 is the preferred site of DBNBS spin trapping in the self-peroxidation reaction of sperm whale metmyoglobin with a single equivalent of hydrogen peroxide.
Chem Res Toxicol
; 16(5): 652-60, 2003 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-12755595