Using anti-Xa level for adjusting intravenous unfractionated heparin infusion in peripartum thromboembolic disease.

BACKGROUND: Intravenous unfractionated heparin infusion is often used to minimize the duration of time without anticoagulation around delivery in pregnant patients with high thrombotic risk. Activated partial thromboplastin time is commonly used to monitor and adjust heparin dose. However, using activated partial thromboplastin time is problematic in pregnancy because activated partial thromboplastin time response to unfractionated heparin is attenuated due to elevated Factor VIII levels and may lead to incorrect dosing. CASE: We report a case of deep venous thrombosis occurring in a term pregnancy managed by intravenous unfractionated heparin adjusted using anti-Xa level around the time of delivery. We modified the intravenous unfractionated heparin nomogram by using anti-Xa levels instead of activated partial thromboplastin time and observed lower dosing of unfractionated heparin than otherwise required to achieve and maintain target levels. CONCLUSION: This report demonstrates the feasibility and effectiveness of using anti-Xa level to monitor and adjust intravenous unfractionated heparin infusion in pregnancy.

Family function in cognitively normal children with epilepsy: impact on competence and problem behaviors.

A cross-sectional cohort of 82 cognitively normal children with epilepsy attending the pediatric neurology clinic, who were aged 6-17 years and who had a similarly aged sibling without seizures or cognitive delay, were identified. The parent was asked to complete the Family Assessment Measure III (FAM-III) as well as the Child Behavior Checklist (CBCL) for both the child with epilepsy and his or her sibling. The Overall Rating Score on FAM-III did not differ significantly from the normative mean, although families scored significantly better on the Involvement subscale and significantly worse on the Role Performance subscale. Moderate correlations were found between competence and behavior problems and family function in both children with epilepsy and their siblings. In families functioning at the highest level, both cohorts did well. In those at the lowest level, approximately half of the children in either cohort had problems. For average functioning families, behavior and competence issues were more frequent in children with epilepsy than their siblings.

Social skills problems in children with epilepsy: prevalence, nature and predictors.

To determine the prevalence, nature, and predictors of social skills impairment in children with epilepsy, 101 parents completed the Social Skills Rating System, the Child Behavior Checklist, a general health questionnaire for both their child with epilepsy (aged 3-17) and his or her sibling, a quality-of-life assessment for the child with epilepsy, and Family Assessment Measure III. Epilepsy-specific variables were recorded for each case. Although children with epilepsy had poorer social skills (P<0.05) and were less assertive (P<0.006) than their siblings, the proportion with clinically significant social skills deficits was low and did not differ between groups (13% vs 7%, P=0.12). Neurological factors were related to social skills, but only presence of a learning disability (odds ratio=8.64, 95% CI=1.87-39.98) and abnormal family function (odds ratio=8.75, 95% CI=1.42-53.83) were strongly predictive of social skills impairment. Lower social skills were moderately correlated with epilepsy-specific and global quality of life (P<0.001).