Detalhe da pesquisa
1.
The intrinsic substrate specificity of the human tyrosine kinome.
Nature
; 629(8014): 1174-1181, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38720073
2.
The feasibility of determining kinetic constants from isothermal titration calorimetry data.
Biophys J
; 121(12): 2474-2484, 2022 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35490299
3.
A multi-laboratory benchmark study of isothermal titration calorimetry (ITC) using Ca2+ and Mg2+ binding to EDTA.
Eur Biophys J
; 50(3-4): 429-451, 2021 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-33864101
4.
Fast and Robust Quantification of Detergent Micellization Thermodynamics from Isothermal Titration Calorimetry.
Anal Chem
; 92(1): 1154-1161, 2020 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31829010
5.
Using modern approaches to sedimentation velocity to detect conformational changes in proteins.
Eur Biophys J
; 49(8): 729-743, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-32761255
6.
Using two-site binding models to analyze microscale thermophoresis data.
Anal Biochem
; 540-541: 64-75, 2018 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29054528
7.
Pathogenic mechanisms underlying X-linked Charcot-Marie-Tooth neuropathy (CMTX6) in patients with a pyruvate dehydrogenase kinase 3 mutation.
Neurobiol Dis
; 94: 237-44, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27388934
8.
Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase.
Proc Natl Acad Sci U S A
; 110(24): 9728-33, 2013 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23716694
9.
Structure-guided development of specific pyruvate dehydrogenase kinase inhibitors targeting the ATP-binding pocket.
J Biol Chem
; 289(7): 4432-43, 2014 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24356970
10.
Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase.
J Biol Chem
; 289(30): 20583-93, 2014 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24895126
11.
A new locus for X-linked dominant Charcot-Marie-Tooth disease (CMTX6) is caused by mutations in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene.
Hum Mol Genet
; 22(7): 1404-16, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23297365
12.
Biophysical and biochemical studies support TP0094 as a phosphotransacetylase in an acetogenic energy-conservation pathway in Treponema pallidum.
PLoS One
; 18(5): e0283952, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37200262
13.
Measuring the KD of Protein-Ligand Interactions Using Microscale Thermophoresis.
Methods Mol Biol
; 2263: 161-181, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33877597
14.
Effect of subunit IV on superoxide generation by Rhodobacter sphaeroides cytochrome bc(1) complex.
Biochim Biophys Acta
; 1787(7): 913-9, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19348783
15.
Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops.
Structure
; 16(12): 1849-59, 2008 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19081061
16.
Biophysical insights into a highly selective l-arginine-binding lipoprotein of a pathogenic treponeme.
Protein Sci
; 27(12): 2037-2050, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30242931
17.
An isolated CLASP TOG domain suppresses microtubule catastrophe and promotes rescue.
Mol Biol Cell
; 29(11): 1359-1375, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29851564
18.
Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice.
Mol Metab
; 12: 12-24, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29656110
19.
The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.
Cell Metab
; 27(6): 1281-1293.e7, 2018 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29779826
20.
Identification of amino acid residues essential for reconstitutive activity of subunit IV of the cytochrome bc1 complex from Rhodobacter sphaeroides.
Biochim Biophys Acta
; 1757(12): 1561-7, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16890186