Detalhe da pesquisa
1.
Discovery of 2-(4-sulfonamidophenyl)-indole 3-carboxamides as potent and selective inhibitors with broad hepatitis C virus genotype activity targeting HCV NS4B.
Bioorg Med Chem Lett
; 26(2): 594-601, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26652483
2.
6-(Azaindol-2-yl)pyridine-3-sulfonamides as potent and selective inhibitors targeting hepatitis C virus NS4B.
Bioorg Med Chem Lett
; 25(4): 781-6, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25613678
3.
Discovery of N-(4'-(indol-2-yl)phenyl)sulfonamides as novel inhibitors of HCV replication.
Bioorg Med Chem Lett
; 23(13): 3942-6, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23683596
4.
Discovery of novel HCV inhibitors: synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B.
Bioorg Med Chem Lett
; 23(13): 3947-53, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23683597
5.
PTC124 targets genetic disorders caused by nonsense mutations.
Nature
; 447(7140): 87-91, 2007 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-17450125
6.
Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy.
J Med Chem
; 59(13): 6086-100, 2016 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27299419
7.
Discovery and Optimization of Small Molecule Splicing Modifiers of Survival Motor Neuron 2 as a Treatment for Spinal Muscular Atrophy.
J Med Chem
; 59(13): 6070-85, 2016 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27299569
8.
Structure-activity relationship (SAR) optimization of 6-(indol-2-yl)pyridine-3-sulfonamides: identification of potent, selective, and orally bioavailable small molecules targeting hepatitis C (HCV) NS4B.
J Med Chem
; 57(5): 2121-35, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24266880
9.
Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy.
Science
; 345(6197): 688-93, 2014 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25104390