Detalhe da pesquisa
1.
Orthogonal Mass Spectrometry-Based Footprinting for Epitope Mapping and Structural Characterization: The IL-6 Receptor upon Binding of Protein Therapeutics.
Anal Chem
; 89(14): 7742-7749, 2017 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28621526
2.
Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and Alanine Shave Mutagenesis.
Anal Chem
; 89(4): 2250-2258, 2017 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28193005
3.
Hydrogen/deuterium exchange mass spectrometry applied to IL-23 interaction characteristics: potential impact for therapeutics.
Expert Rev Proteomics
; 12(2): 159-69, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25711416
4.
Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development.
J Org Chem
; 80(14): 7019-32, 2015 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26151079
5.
Metabolomics in the pharmaceutical industry.
Drug Discov Today Technol
; 13: 25-31, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26190680
6.
Optimization and simulation of tandem column supercritical fluid chromatography separations using column back pressure as a unique parameter.
Anal Chem
; 86(8): 4033-40, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24661124
7.
Development of a highly sensitive liquid chromatography/tandem mass spectrometry method to quantify total and free levels of a target protein, interferon-gamma-inducible protein-10, at picomolar levels in human serum.
Rapid Commun Mass Spectrom
; 28(13): 1535-43, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24861605
8.
Characterization of disulfide linkages in recombinant human granulocyte-colony stimulating factor.
Rapid Commun Mass Spectrom
; 27(9): 940-6, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23592195
9.
Approach to evaluating dried blood spot sample stability during drying process and discovery of a treated card to maintain analyte stability by rapid on-card pH modification.
Anal Chem
; 83(23): 9033-8, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21995953
10.
Correction to "Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development".
J Org Chem
; 80(18): 9370, 2015 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26332153
11.
Development and implementation of a stereoselective normal-phase liquid chromatography-tandem mass spectrometry method for the determination of intrinsic metabolic clearance in human liver microsomes.
J Chromatogr B Analyt Technol Biomed Life Sci
; 875(1): 154-60, 2008 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18722827
12.
Probing Conformational Dynamics of Tau Protein by Hydrogen/Deuterium Exchange Mass Spectrometry.
J Am Soc Mass Spectrom
; 29(1): 174-182, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28971440
13.
An automated high throughput liquid chromatography-mass spectrometry process to assess the metabolic stability of drug candidates.
Assay Drug Dev Technol
; 5(2): 247-64, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17477833
14.
The role of chromatographic and chiroptical spectroscopic techniques and methodologies in support of drug discovery for atropisomeric drug inhibitors of Bruton's tyrosine kinase.
J Chromatogr A
; 1487: 116-128, 2017 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28131592
15.
Tiered analytics for purity assessment of macrocyclic peptides in drug discovery: Analytical consideration and method development.
J Pharm Biomed Anal
; 138: 166-174, 2017 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28213177
16.
Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry.
J Am Soc Mass Spectrom
; 28(5): 795-802, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27527097
17.
Chromatography-based methods for determining molar extinction coefficients of cytotoxic payload drugs and drug antibody ratios of antibody drug conjugates.
J Chromatogr A
; 1455: 133-139, 2016 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27286648
18.
Enantioselective chromatography in drug discovery.
Drug Discov Today
; 10(8): 571-7, 2005 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15837600
19.
Characterization and quantification of histidine degradation in therapeutic protein formulations by size exclusion-hydrophilic interaction two dimensional-liquid chromatography with stable-isotope labeling mass spectrometry.
J Chromatogr A
; 1426: 133-9, 2015 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26674608
20.
Utility of Ion Mobility Mass Spectrometry for Drug-to-Antibody Ratio Measurements in Antibody-Drug Conjugates.
J Am Soc Mass Spectrom
; 26(10): 1791-4, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26122520