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1.
Bratisl Lek Listy ; 116(1): 51-6, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25666963

RESUMO

INTRODUCTION: Alcohol consumption is frequently associated with gastric mucosal lesions. The purpose of this study was to determine the effect of Coenzyme-Q10 (CoQ10) supplementation on the ethanol-induced gastric mucosal damage in a rat model. MATERIAL AND METHOD: Sixty-four female wistar albino rats were randomly divided into 8 groups (n = 8). Studies were performed in ethanol induced gastric ulcer model in Wistar albino rats. Famotidine at a dose of 5 mg/kg or 20 mg/kg and CoQ10 at a single dose of 10 mg/kg or 20 mg/kg and 30 mg/kg for 7 days were administered as pretreatment. All the rats in study groups received 2 ml/kg ethanol 95 % intragastrically, 30 minutes after pretreatment. Four hour after ethanol administration, all rats were sacrificed and their stomachs were removed under ketamin anaesthesia. Gastric protection was evaluated by measuring the ulcer index, MDA concentrations, and histopathological studies. RESULTS AND DISCUSSION: Rats pretreated either with famotidine or CoQ10 had significantly diminished gastric mucosal damage which was assessed with gross and microscopic analysis (p < 0.00625). MDA levels were significantly lower in famotidine 20 mg/kg and CoQ10 pretreatment for 7 days group (p < 0.00625).


Assuntos
Antiulcerosos/farmacologia , Mucosa Gástrica/efeitos dos fármacos , Úlcera Gástrica/prevenção & controle , Ubiquinona/análogos & derivados , Vitaminas/farmacologia , Animais , Relação Dose-Resposta a Droga , Etanol , Feminino , Mucosa Gástrica/patologia , Extratos Vegetais/farmacologia , Distribuição Aleatória , Ratos , Ratos Wistar , Úlcera Gástrica/induzido quimicamente , Ubiquinona/farmacologia
3.
Endocr Regul ; 41(4): 143-8, 2007 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-18257650

RESUMO

OBJECTIVE: The aim of this study was to assess the factors that might predict patients at increased risk for inadvertent parathyroidectomy and postoperative symptomatic hypocalcemia during thyroidectomy. METHODS: Demographic data as well as the data on preoperative diagnosis, preoperative ultrasonography reports, operation reports, histological findings, and postoperative symptomatic hypocalcemia were collected. A total of 273 (83 male and 190 female patients) thyroid operations were included in this study. RESULTS: Histopathological examination identified inadvertent parathyroidectomy in 10 (3.7%) cases. Statistical analysis identified the presence of cervical lymphadenopathy as detected by preoperative ultrasonography as a risk factor for inadvertent parathyroidectomy. In 57 patients (20.9%) clinically symptomatic postoperative hypocalcemia was observed. However, the difference in the frequency of such hypocalcemia between the patients with and without inadvertent parathyroidectomy was not significant. Statistical evaluation identified total thyroidectomy as a risk factor for postoperative hypocalcemia (p<0.005). CONCLUSION: Due to our experience, inadvertent parathyroidectomy is not a rare entity during thyroidectomy and the presence of cervical lymphadenopathy, as observed by preoperative ultrasonography, is the only risk factor for inadvertent parathyroidectomy. In contrast, no association between inadvertent parathyroidectomy and postoperative hypocalcemia was detected. Total thyroidectomy was found to be the sole risk factor for symptomatic temporary hypocalcemia.


Assuntos
Hipocalcemia/etiologia , Complicações Intraoperatórias , Paratireoidectomia , Tireoidectomia/efeitos adversos , Adulto , Idoso , Feminino , Humanos , Linfonodos/diagnóstico por imagem , Doenças Linfáticas/complicações , Doenças Linfáticas/cirurgia , Masculino , Pessoa de Meia-Idade , Pescoço , Estudos Retrospectivos , Fatores de Risco , Doenças da Glândula Tireoide/cirurgia , Ultrassonografia
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