Detalhe da pesquisa
1.
G protein-receptor kinases 5/6 are the key regulators of G protein-coupled receptor 35-arrestin interactions.
J Biol Chem
; 299(10): 105218, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37660910
2.
G protein-coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin.
J Biol Chem
; 298(10): 102421, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36030052
3.
An effective kinase inhibition strategy for metastatic recurrent childhood medulloblastoma.
J Neurooncol
; 163(3): 635-645, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37354357
4.
Functional characterization of a PROTAC directed against BRAF mutant V600E.
Nat Chem Biol
; 16(11): 1170-1178, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32778845
5.
A drug discovery platform to identify compounds that inhibit EGFR triple mutants.
Nat Chem Biol
; 16(5): 577-586, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32094923
6.
Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport.
J Biol Chem
; 294(12): 4546-4571, 2019 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30696771
7.
Small molecules reveal an alternative mechanism of Bax activation.
Biochem J
; 473(8): 1073-83, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26916338
8.
PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma.
J Transl Med
; 14: 67, 2016 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26952093
9.
Recent progress on MAP kinase pathway inhibitors.
Bioorg Med Chem Lett
; 25(19): 4047-56, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26298497
10.
Use of kinase inhibitors to correct ΔF508-CFTR function.
Mol Cell Proteomics
; 11(9): 745-57, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22700489
11.
Which Small Molecule? Selecting Chemical Probes for Use in Cancer Research and Target Validation.
Cancer Discov
; 13(10): 2150-2165, 2023 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37712569
12.
Targeting tumour-associated macrophages in hodgkin lymphoma using engineered extracellular matrix-mimicking cryogels.
Biomaterials
; 297: 122121, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37075613
13.
Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor.
ACS Med Chem Lett
; 14(2): 199-210, 2023 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36793435
14.
Phenolic Lipids Derived from Cashew Nut Shell Liquid to Treat Metabolic Diseases.
J Med Chem
; 65(3): 1961-1978, 2022 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35089724
15.
Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup.
Bioorg Med Chem Lett
; 21(15): 4436-40, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21733693
16.
6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases.
Proc Natl Acad Sci U S A
; 105(8): 2773-8, 2008 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-18287036
17.
Pharmacological Targeting of Executioner Proteins: Controlling Life and Death.
J Med Chem
; 64(9): 5276-5290, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33939407
18.
The PKN1- TRAF1 signaling axis as a potential new target for chronic lymphocytic leukemia.
Oncoimmunology
; 10(1): 1943234, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34589290
19.
Emergence of Enzalutamide Resistance in Prostate Cancer is Associated with BCL-2 and IKKB Dependencies.
Clin Cancer Res
; 27(8): 2340-2351, 2021 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33542074
20.
Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma.
J Med Chem
; 64(15): 11129-11147, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34291633