Detalhe da pesquisa
1.
Discovery of benzothiazoles as antimycobacterial agents: Synthesis, structure-activity relationships and binding studies with Mycobacterium tuberculosis decaprenylphosphoryl-ß-D-ribose 2'-oxidase.
Bioorg Med Chem
; 23(24): 7694-710, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26643218
2.
Pradefovir: a prodrug that targets adefovir to the liver for the treatment of hepatitis B.
J Med Chem
; 51(3): 666-76, 2008 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18173234
3.
Synthesis and characterization of a novel liver-targeted prodrug of cytosine-1-beta-D-arabinofuranoside monophosphate for the treatment of hepatocellular carcinoma.
J Med Chem
; 49(26): 7711-20, 2006 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17181153
4.
Nitroarenes as Antitubercular Agents: Stereoelectronic Modulation to Mitigate Mutagenicity.
ChemMedChem
; 11(3): 331-9, 2016 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26751718
5.
Adenosine kinase inhibitors. 4. 6,8-Disubstituted purine nucleoside derivatives. Synthesis, conformation, and enzyme inhibition.
J Med Chem
; 48(9): 3389-99, 2005 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-15857145
6.
Adenosine kinase inhibitors. 6. Synthesis, water solubility, and antinociceptive activity of 5-phenyl-7-(5-deoxy-beta-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidines substituted at C4 with glycinamides and related compounds.
J Med Chem
; 48(24): 7808-20, 2005 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16302820
7.
Adenosine kinase inhibitors. 5. Synthesis, enzyme inhibition, and analgesic activity of diaryl-erythro-furanosyltubercidin analogues.
J Med Chem
; 48(20): 6430-41, 2005 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16190769
8.
Structure guided lead generation for M. tuberculosis thymidylate kinase (Mtb TMK): discovery of 3-cyanopyridone and 1,6-naphthyridin-2-one as potent inhibitors.
J Med Chem
; 58(2): 753-66, 2015 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25486447
9.
Adenosine kinase inhibitors. 3. Synthesis, SAR, and antiinflammatory activity of a series of l-lyxofuranosyl nucleosides.
J Med Chem
; 46(22): 4750-60, 2003 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-14561094
10.
Quinolinyl Pyrimidines: Potent Inhibitors of NDH-2 as a Novel Class of Anti-TB Agents.
ACS Med Chem Lett
; 3(9): 736-40, 2012 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900541
11.
Design, synthesis, and characterization of a series of cytochrome P(450) 3A-activated prodrugs (HepDirect prodrugs) useful for targeting phosph(on)ate-based drugs to the liver.
J Am Chem Soc
; 126(16): 5154-63, 2004 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-15099098