RESUMO
The one-step synthesis of [14 C]formamidine acetate from [14 C]barium cyanamide is described with product characterization by TLC and proton NMR.
Assuntos
Amidinas , Cianamida , Espectroscopia de Ressonância MagnéticaRESUMO
An efficient method is described to radiolabel several dopamine D2 receptor agonists with tritium at high specific activity.
Assuntos
Agonistas de Dopamina/farmacologia , Receptores de Dopamina D2/efeitos dos fármacos , Trítio/química , Agonistas de Dopamina/química , Espectroscopia de Ressonância MagnéticaRESUMO
Potential E- and P-selectin inhibitors were synthesized to explore a hydrophobic area on the E-selectin surface and the PSGL-1 protein binding site on the P-selectin surface that was recently defined by crystallography. Three series of mannose-based compounds (libraries A, B, and C) were synthesized using solution phase parallel synthesis. Biological evaluation of these compounds was done using two ELISA-based assays and transferred NOE (trNOE) experiments. Some of the compounds showed better activity than sLe(x) in the P-selectin assay.