Detalhe da pesquisa
1.
Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura.
N Engl J Med
; 374(6): 511-22, 2016 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26863353
2.
Reperfusion of cerebral artery thrombosis by the GPIb-VWF blockade with the Nanobody ALX-0081 reduces brain infarct size in guinea pigs.
Blood
; 121(25): 5088-97, 2013 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23589671
3.
Evaluation of efficacy and safety of the anti-VWF Nanobody ALX-0681 in a preclinical baboon model of acquired thrombotic thrombocytopenic purpura.
Blood
; 120(17): 3603-10, 2012 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22948047
4.
Antithrombotic drug candidate ALX-0081 shows superior preclinical efficacy and safety compared with currently marketed antiplatelet drugs.
Blood
; 118(3): 757-65, 2011 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21576702
5.
CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells.
Proc Natl Acad Sci U S A
; 107(47): 20565-70, 2010 Nov 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21059953
6.
A biomarker assay validation approach tailored to the context of use and bioanalytical platform.
Bioanalysis
; 15(13): 757-771, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37526064
7.
Update to the European Bioanalysis Forum recommendation on biomarkers assays; bringing context of use into practice.
Bioanalysis
; 12(20): 1427-1437, 2020 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-33025797
8.
Platelet microparticle formation and thrombin generation under high shear are effectively suppressed by a monoclonal antibody against GPIba.
Thromb Haemost
; 96(6): 774-80, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17139372
9.
Synergistic effect of thrombin on collagen-induced platelet procoagulant activity is mediated through protease-activated receptor-1.
Arterioscler Thromb Vasc Biol
; 25(7): 1499-505, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15845904
10.
von Willebrand factor but not alpha-thrombin binding to platelet glycoprotein Ibalpha is influenced by the HPA-2 polymorphism.
Arterioscler Thromb Vasc Biol
; 23(7): 1302-7, 2003 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12775575
11.
How does agkicetin-C bind on platelet glycoprotein Ibalpha and achieve its platelet effects?
Toxicon
; 45(5): 561-70, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15777951
12.
The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis.
Arthritis Res Ther
; 17: 135, 2015 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25994180
13.
The in vitro effect of the new antithrombotic drug candidate ALX-0081 on blood samples of patients undergoing percutaneous coronary intervention.
Thromb Haemost
; 106(1): 165-71, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21655675
14.
The GPIbalpha-thrombin interaction: far from crystal clear.
Trends Mol Med
; 10(1): 33-9, 2004 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-14720584
15.
Relation of endothelial function to residual platelet reactivity after clopidogrel in patients with stable angina pectoris undergoing percutaneous coronary intervention.
Am J Cardiol
; 105(3): 333-8, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20102944
16.
Inhibition of platelet glycoprotein Ib and its antithrombotic potential.
Curr Pharm Des
; 13(26): 2684-97, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17897012
17.
Shielding of the A1 domain by the D'D3 domains of von Willebrand factor modulates its interaction with platelet glycoprotein Ib-IX-V.
J Biol Chem
; 281(8): 4699-707, 2006 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-16373331
18.
Role of glycoprotein Ibalpha in phagocytosis of platelets by macrophages.
Transfusion
; 46(12): 2090-9, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17176320
19.
Identification of residues within human glycoprotein VI involved in the binding to collagen: evidence for the existence of distinct binding sites.
J Biol Chem
; 279(50): 52293-9, 2004 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-15466473
20.
Integrin alphaIIbbeta3 and shear-dependent action of glycoprotein Ibalpha stimulate platelet-dependent thrombin formation in stirred plasma.
J Lab Clin Med
; 141(5): 350-8, 2003 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-12761479