Detalhe da pesquisa
1.
The Role of N-α-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting.
Mol Cell
; 68(1): 89-103.e7, 2017 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28943313
2.
NMR-based fragment screening and lead discovery accelerated by principal component analysis.
J Biomol NMR
; 73(12): 675-685, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31541395
3.
The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.
Nat Chem Biol
; 13(3): 317-324, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28114273
4.
Targeting lysine specific demethylase 4A (KDM4A) tandem TUDOR domain - A fragment based approach.
Bioorg Med Chem Lett
; 28(10): 1708-1713, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29691138
5.
Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation.
Nucleic Acids Res
; 40(11): 4841-9, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22362737
6.
Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor.
Proc Natl Acad Sci U S A
; 108(39): 16212-6, 2011 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21908710
7.
Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds.
J Med Chem
; 67(8): 6456-6494, 2024 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38574366
8.
Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site.
Sci Rep
; 12(1): 14561, 2022 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36028520
9.
Dynamics of histone lysine methylation: structures of methyl writers and erasers.
Prog Drug Res
; 67: 107-24, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21141727
10.
Development of spin-labeled pargyline analogues as specific inhibitors of human monoamine oxidases A and B.
Biochemistry
; 48(18): 3928-35, 2009 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19296688
11.
Molecular and mechanistic properties of the membrane-bound mitochondrial monoamine oxidases.
Biochemistry
; 48(20): 4220-30, 2009 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19371079
12.
Membrane tetraheme cytochrome c(m552) of the ammonia-oxidizing nitrosomonas europaea: a ubiquinone reductase.
Biochemistry
; 47(25): 6539-51, 2008 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18505274
13.
Characterization of detergent purified recombinant rat liver monoamine oxidase B expressed in Pichia pastoris.
Protein Expr Purif
; 59(2): 349-56, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18424170
14.
Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315.
J Med Chem
; 61(15): 6647-6657, 2018 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30004704
15.
Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5.
Acta Crystallogr F Struct Biol Commun
; 73(Pt 3): 116-122, 2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28291746
16.
Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8.
ACS Med Chem Lett
; 7(12): 1102-1106, 2016 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27994746
17.
An analog of BIX-01294 selectively inhibits a family of histone H3 lysine 9 Jumonji demethylases.
J Mol Biol
; 416(3): 319-27, 2012 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-22227394
18.
Structural basis for human PHF2 Jumonji domain interaction with metal ions.
J Mol Biol
; 406(1): 1-8, 2011 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-21167174
19.
Coordinated methyl-lysine erasure: structural and functional linkage of a Jumonji demethylase domain and a reader domain.
Curr Opin Struct Biol
; 21(6): 750-60, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21872465
20.
A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability.
Nat Struct Mol Biol
; 18(1): 42-8, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21151116