Detalhe da pesquisa
1.
6,6'-Bieckol suppresses inflammatory responses by down-regulating nuclear factor-κB activation via Akt, JNK, and p38 MAPK in LPS-stimulated microglial cells.
Immunopharmacol Immunotoxicol
; 38(3): 244-52, 2016 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-27121731
2.
A novel micellular fluorogenic substrate for quantitating the activity of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma (PLCγ) enzymes.
PLoS One
; 19(3): e0299541, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38551930
3.
A novel fluorogenic reporter substrate for 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCγ2): Application to high-throughput screening for activators to treat Alzheimer's disease.
SLAS Discov
; 28(4): 170-179, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36933698
4.
Targets for AD treatment: conflicting messages from γ-secretase inhibitors.
J Neurochem
; 117(3): 359-74, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21320126
5.
An Avocado Extract Enriched in Mannoheptulose Prevents the Negative Effects of a High-Fat Diet in Mice.
Nutrients
; 14(1)2021 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-35011030
6.
Meroterpenoid-Rich Fraction of the Ethanol Extract of Sargassum Serratifolium Suppresses Collagen-Induced Rheumatoid Arthritis in DBA/1J Mice Via Inhibition of Nuclear Factor κB Activation.
Mol Nutr Food Res
; 64(3): e1900373, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31900972
7.
Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse.
Alzheimers Dement (N Y)
; 4: 37-45, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29955650
8.
Sargachromenol protects against vascular inflammation by preventing TNF-α-induced monocyte adhesion to primary endothelial cells via inhibition of NF-κB activation.
Int Immunopharmacol
; 42: 81-89, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27902962
9.
Polylactic acid (PLA) controlled delivery carriers for biomedical applications.
Adv Drug Deliv Rev
; 107: 163-175, 2016 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27426411
10.
Differential Rickettsial Transcription in Bloodfeeding and Non-Bloodfeeding Arthropod Hosts.
PLoS One
; 11(9): e0163769, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27662479
11.
Anti-Inflammatory Effect of Ethanolic Extract of Sargassum serratifolium in Lipopolysaccharide-Stimulated BV2 Microglial Cells.
J Med Food
; 19(11): 1023-1031, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27845863
12.
Dieckol enhances the expression of antioxidant and detoxifying enzymes by the activation of Nrf2-MAPK signalling pathway in HepG2 cells.
Food Chem
; 174: 538-46, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25529716
13.
Nicotine lowers the secretion of the Alzheimer's amyloid beta-protein precursor that contains amyloid beta-peptide in rat.
J Alzheimers Dis
; 4(5): 405-15, 2002 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-12446972
14.
Genomic diversification in strains of Rickettsia felis Isolated from different arthropods.
Genome Biol Evol
; 7(1): 35-56, 2014 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-25477419
15.
Phlorofucofuroeckol A suppresses expression of inducible nitric oxide synthase, cyclooxygenase-2, and pro-inflammatory cytokines via inhibition of nuclear factor-κB, c-Jun NH2-terminal kinases, and Akt in microglial cells.
Inflammation
; 36(2): 259-71, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22993079
16.
Cytoprotective effects of phlorofucofuroeckol A isolated from Ecklonia stolonifera against tacrine-treated HepG2 cells.
Fitoterapia
; 83(6): 1060-7, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22613808
17.
Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and hepatoprotective properties in tacrine-treated HepG2 cells.
J Agric Food Chem
; 60(21): 5340-9, 2012 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-22587607
18.
Phlorofucofuroeckol A inhibits the LPS-stimulated iNOS and COX-2 expressions in macrophages via inhibition of NF-κB, Akt, and p38 MAPK.
Toxicol In Vitro
; 25(8): 1789-95, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21963823
19.
Preclinical investigation of the topical administration of phenserine: transdermal flux, cholinesterase inhibition, and cognitive efficacy.
J Pharmacol Exp Ther
; 321(1): 353-61, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17255466
20.
Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent.
Proc Natl Acad Sci U S A
; 102(47): 17213-8, 2005 Nov 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-16275899