Detalhe da pesquisa
1.
Preclinical Bioavailability Strategy for Decisions on Clinical Drug Formulation Development: An In Depth Analysis.
Mol Pharm
; 15(7): 2633-2645, 2018 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29799758
2.
Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates.
Mol Pharm
; 12(2): 520-32, 2015 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25496026
3.
Physiology-based IVIVE predictions of tramadol from in vitro metabolism data.
Pharm Res
; 32(1): 260-74, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25048637
4.
Mechanistic understanding of brain drug disposition to optimize the selection of potential neurotherapeutics in drug discovery.
Pharm Res
; 31(8): 2203-19, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24623476
5.
Physiologically-based PK/PD modelling of therapeutic macromolecules.
Pharm Res
; 26(12): 2543-50, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19847627
6.
Predicting oral clearance in humans: how close can we get with allometry?
Clin Pharmacokinet
; 47(1): 35-45, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18076217
7.
Strategies for Determining Correct Cytochrome P450 Contributions in Hepatic Clearance Predictions: In Vitro-In Vivo Extrapolation as Modelling Approach and Tramadol as Proof-of Concept Compound.
Eur J Drug Metab Pharmacokinet
; 42(3): 537-543, 2017 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-27317395
8.
IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes.
Eur J Pharm Sci
; 96: 626-642, 2017 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27693299
9.
IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results.
Eur J Pharm Sci
; 96: 610-625, 2017 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27816631
10.
IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds.
Eur J Pharm Sci
; 96: 598-609, 2017 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27671970
11.
Use of physiologically relevant biopharmaceutics tools within the pharmaceutical industry and in regulatory sciences: Where are we now and what are the gaps?
Eur J Pharm Sci
; 91: 84-90, 2016 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27283487
12.
Single-Dose Pharmacokinetic Study of Tramadol Extended-Release Tablets in Children and Adolescents.
Clin Pharmacol Drug Dev
; 5(5): 343-53, 2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27138295
13.
Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation.
AAPS J
; 17(6): 1376-87, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26209290
14.
Galantamine population pharmacokinetics in patients with Alzheimer's disease: modeling and simulations.
J Clin Pharmacol
; 43(5): 514-23, 2003 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-12751272
15.
Galantamine pharmacokinetics, safety, and tolerability profiles are similar in healthy Caucasian and Japanese subjects.
J Clin Pharmacol
; 42(9): 1002-10, 2002 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-12211216
16.
The successes and failures of physiologically based pharmacokinetic modeling: there is room for improvement.
Expert Opin Drug Metab Toxicol
; 10(5): 631-5, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24517185
17.
Towards a better prediction of peak concentration, volume of distribution and half-life after oral drug administration in man, using allometry.
Clin Pharmacokinet
; 50(5): 307-18, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21456631
18.
Variability and impact on design of bioequivalence studies.
Basic Clin Pharmacol Toxicol
; 106(3): 146-53, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20041877
19.
Bioavailability and bioequivalence: focus on physiological factors and variability.
Pharm Res
; 25(8): 1956-62, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18551249
20.
Including information on the therapeutic window in bioequivalence acceptance.
Pharm Res
; 25(11): 2628-38, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18636320