The stability of blood eosinophils in stable chronic obstructive pulmonary disease: a retrospective study in Belgian primary care.

BACKGROUND: Blood eosinophil counts (BEC) were recently included in the 2019 Global Initiative for Obstructive Lung Disease (GOLD) guideline as an easily accessible theragnostic biomarker for Chronic Obstructive Pulmonary Disease (COPD). However, the stability of BEC remains insufficiently studied. METHODS: We conducted a retrospective study in six primary care practices in Belgium on data from Electronic Health Records of stable COPD patients, to characterise the stability of blood eosinophils over time. We report the percentage of patients with BEC persistently below or above the 2019 GOLD guideline thresholds (100 and 300 cells/µL). For each patient the mean, standard deviation (SD) and relative standard deviation (RSD) of the BEC were calculated to determine the intra-patient variability. RESULTS: Ninety-eight patients were included, yielding 1082 eosinophil measurements (median 8 measurements/patient), with BEC ranging between 0 and 1504 cells/µL. Four (4.1%) patients had BEC persistently below 100 cells/µL, 34 (34.7%) had measurements persistently above this threshold. Approximately half of the patients (51.0%) had BEC persistently below 300 cells/µL and 3 (3.1%) patients had counts persistently above this threshold. 28.6% of patients crossed both threshold values throughout the registration period. The mean BEC per patient ranged between 15 and 846 cells/µL with an intra-patient SD between 5 and 658 cells/µL. The mean intra-patient RSD was 0.46. There was a significant strong positive correlation (Pearson analyses) between the mean BEC and SD (r = 0.765; n = 98). Simple linear regression was used to further describe the influence of the mean eosinophil count on the SD (B = 0.500; 95%CI 0.415-0.586; n = 98; p < 0.001). CONCLUSION: BEC can be variable in individual COPD patients. Therefore, the use of a single measurement to guide therapeutic decisions remains debatable. Further prospective research remains necessary to validate the reproducibility of this biomarker.

Notification about influenza vaccination in Belgium: a descriptive study of how people want to be informed.

BACKGROUND: Influenza causes a substantial socioeconomic burden. In Belgium, only 54% of the target group receives an annual vaccination. Patient reminder/recall systems are effective in improving vaccination rates in primary care, but little is known about patients' preferences on notification of influenza vaccination. AIMS: To evaluate whether general practice patients wish to be notified of the possibility of receiving influenza immunisation, and how. METHODS: In January 2008, 750 questionnaires were handed out to all consecutive patients aged >18 years in three Belgian general practices. Main outcome measures were the percentage wanting to be notified, demographic and medical factors influencing the information needs of the patients and the specific way in which patients wanted to be notified. RESULTS: About 80% of respondents wanted to be notified of the possibility of influenza vaccination. Logistic regression analysis showed that those who had previously been vaccinated particularly wished to be notified, both in the total population (OR 4.45; 95% CI 2.87 to 6.90; p<0.0001) and in the subgroup of high-risk individuals (OR 9.05; 95% CI 4.47 to 18.33; p<0.0001). More than 85% of the participants wanted to be informed by their family physician, mostly during a consultation regardless of the reason for the encounter. The second most preferred option was a letter sent by the family physician enclosing a prescription. CONCLUSIONS: The majority of general practice patients want to be notified of the possibility of influenza vaccination. More than 85% of participants who wanted to be notified preferred to receive this information from their family physician, mostly by personal communication during a regular visit. However, since a large minority preferred to be addressed more proactively (letter, telephone call, e-mail), GPs should be encouraged to combine an opportunistic approach with a proactive one.

A Training Game for Students Considering Family Medicine: an Educational Project Report.

The Groningen Institute Model for Management in Care Services aims to prepare medical students for their complex tasks as family physicians, based on the CanMEDS framework. Although initially developed for pharmacy students, the present paper reports on the eight-year experience with GIMMICS for family physician students at the Vrije Universiteit Brussel. The Groningen Institute Model for Management in Care Services is a training game that simulates real-life situations in a structured and supervised setting. It offers students the possibility to practice clinical, practical, and communicational skills. Students install and manage their group practices, hold consultations with simulated patients, participate in several assignments and collaborate with pharmacy students. Feedback sessions showed that the training game is well-received by the students. A self-assessment questionnaire comprised of 23 questions on significant aspects of the seven CanMEDS roles showed significantly higher scores at the end of the game for 17 questions (p<0.05, Wilcoxon signed-rank test ). GIMMICS is a valuable linking pin between the different learning methods in medical education and clinical practice, helping students to improve themselves in the CanMEDS roles. However, simulation-based medical education requires significant time and resource investment.

Association of Dietary Habits and Interest for Food and Science versus Weight Status in Children Aged 8 to 18 Years.

Introduction: This study aims to describe the association between dietary habits and weight status and the interest in food and science. Methods: We examined in a cross-sectional study 525 children aged between 8 and 18 years, who attended the Brussels Food Fair or the Belgian Science Day in 2013. They were divided into three groups: special interest in science, special interest in food, and a general control group. They completed a questionnaire, and body parameters were measured. The weight status of the children was identified using the growth charts and the calculated BMI. Results: In total, 525 children were included: 290 children in the reference group, 194 in the food group, and 41 in the science group. The prevalence of overweight and obesity was 28% in the general control group, 14% in the food group, and 15% in the science group. Breakfast and dinner were skipped more often by children with overweight or obesity. Children from the food and science groups had more sweets and meat, had less fruit, and skipped less meals. Conclusion: In our study, 28% of the reference group had overweight or obesity. The children with special interest in food or science differed from the control group.